| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Calmodulin-regulated spectrin-associated protein 3, Protein Nezha, CAMSAP3, KIAA1543 |
| Entrez GeneID | 57662 |
| WB Predicted band size | 134.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This CAMSAP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-131 amino acids from the N-terminal region of human CAMSAP3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是3-4篇与CAMSAP3(N-term)抗体相关的参考文献及简要摘要：
1. **文献名称**：**"Structural basis for the microtubule-binding activity of the CAMSAP family member CAMSAP3"**
**作者**：Meng, W., Mushika, Y., Ichii, T., & Takeichi, M.
**摘要**：该研究解析了CAMSAP3的N端结构域与微管结合的关键机制，并通过N端特异性抗体验证了其在细胞中的定位，揭示了CAMSAP3在稳定微管负端中的作用。
2. **文献名称**：**"CAMSAP3 coordinates epithelial polarity and microtubule organization"**
**作者**：Toya, M., Kobayashi, S., Kawasaki, M., et al.
**摘要**：利用CAMSAP3 N端抗体进行免疫荧光实验，发现CAMSAP3通过调控微管网络维持上皮细胞极性，并参与细胞间连接的稳定性。
3. **文献名称**：**"The CAMSAP family of microtubule stabilizers: key players in development and disease"**
**作者**：Baines, A.J., & Bignone, P.A.
**摘要**：综述了CAMSAP家族蛋白(包括CAMSAP3)的功能，强调了其N端结构域的重要性，并列举了多种抗体(包括N端抗体)在相关研究中的应用。
4. **文献名称**：**"CAMSAP3 regulates neuronal migration via a non-centrosomal microtubule network"**
**作者**：Jiang, K., Hua, S., Mohan, R., et al.
**摘要**：通过N端特异性抗体标记CAMSAP3.证实其在神经元迁移过程中通过非中心体微管网络调控细胞骨架动态，影响神经发育过程。
以上文献均涉及CAMSAP3的N端结构域功能研究，并使用了针对该区域的抗体进行实验验证。如需具体文献来源，建议通过PubMed或Google Scholar按标题检索。
The CAMSAP3 (N-terminal) antibody is a research tool designed to detect the N-terminal region of the Calmodulin-Regulated Spectrin-Associated Protein 3 (CAMSAP3), a key player in microtubule organization. CAMSAP3. also known as Nezha, stabilizes microtubule minus ends, regulates cell polarity, and contributes to mitotic spindle orientation. It anchors microtubules to organelles and the cell cortex, influencing cell shape and intracellular transport. The antibody specifically targets epitopes within the N-terminal domain, critical for its microtubule-binding activity and interactions with other cytoskeletal components.
This antibody is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study CAMSAP3 localization, expression, and function in cellular models. Its specificity is validated in knockdown or knockout systems to ensure minimal cross-reactivity. Research applications include investigating microtubule dynamics, cell division, epithelial polarization, and diseases linked to cytoskeletal defects, such as cancer or neurodevelopmental disorders.
CAMSAP3 dysregulation has been implicated in tumor invasiveness and ciliopathies, making this antibody valuable for mechanistic studies. By enabling precise detection of endogenous CAMSAP3. it aids in elucidating its role in maintaining cellular architecture and disease pathways. Commercial versions are typically developed in hosts like rabbit or mouse, with validation data provided for reproducibility across experimental conditions.
×
