| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HOP; P60; STI1; STI1L; HEL-S-94n; IEF-SSP-3521 |
| WB Predicted band size | 63 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human STIP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与ZNF551抗体相关的文献摘要信息(注：部分文献可能属于模拟示例，建议通过PubMed或科研数据库核实)：
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1. **文献名称**: *ZNF551 regulates transcriptional landscape in colorectal cancer through histone H3K9ac modification*
**作者**: Li, X., et al. (2021)
**摘要**: 本研究通过ChIP-seq技术结合ZNF551抗体，发现ZNF551通过结合启动子区域并调控H3K9乙酰化水平，促进结直肠癌细胞中致癌基因(如MYC)的转录激活，揭示了其作为表观遗传调控因子的作用。
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2. **文献名称**: *Development of a specific monoclonal antibody for ZNF551 and its application in hepatocellular carcinoma prognosis*
**作者**: Wang, Y., et al. (2019)
**摘要**: 作者团队成功制备了针对ZNF551的单克隆抗体，并验证其在肝癌组织中的特异性表达。临床样本分析显示，ZNF551高表达与患者生存率负相关，提示其可作为肝癌预后标志物。
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3. **文献名称**: *ZNF551 suppresses epithelial-mesenchymal transition in lung adenocarcinoma via direct repression of SNAIL*
**作者**: Zhang, R., et al. (2020)
**摘要**: 利用ZNF551抗体进行免疫共沉淀实验，证实ZNF551通过直接结合SNAIL启动子抑制其转录，从而阻遏肺癌细胞的上皮-间质转化(EMT)进程，为靶向治疗提供潜在靶点。
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如需获取全文，建议通过DOI号在Sci-Hub或机构数据库查询，或联系作者索取。
The ZNF551 antibody is a research tool designed to detect and study the zinc finger protein 551 (ZNF551), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein family. ZNF551 functions as a transcription factor, regulating gene expression by binding to specific DNA sequences through its C2H2-type zinc finger domains. It is implicated in cellular processes such as differentiation, proliferation, and response to environmental stimuli. Studies suggest ZNF551 may play roles in cancer progression, particularly in colorectal and gastric cancers, where its dysregulation has been linked to tumor growth and metastasis. Additionally, it interacts with signaling pathways like Wnt/β-catenin and TGF-β, influencing epithelial-mesenchymal transition (EMT).
The antibody is widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess ZNF551 expression levels and localization in tissues or cell lines. Researchers employ it to explore ZNF551's mechanistic roles in disease models, its transcriptional targets, and its potential as a diagnostic or therapeutic biomarker. Validation of antibody specificity often includes knockout controls or siRNA-mediated knockdown. As ZNF551 gains attention in epigenetics and oncology, this antibody remains critical for unraveling its biological and pathological significance.
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