| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Krueppel-like factor 15, Kidney-enriched krueppel-like factor, KLF15, KKLF |
| Entrez GeneID | 28999 |
| WB Predicted band size | 44.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This KLF15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 372-398 amino acids from the C-terminal region of human KLF15. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于KLF15抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: *"Krüppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation"*
**作者**: Gray S, et al.
**摘要**: 该研究利用KLF15抗体探究了KLF15在骨骼肌脂质代谢中的作用，发现其通过调控脂质转运相关基因表达，影响运动诱导的代谢适应，缺乏KLF15的小鼠表现出脂质利用障碍和运动耐力下降。
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2. **文献名称**: *"The Krüppel-like factor 15 regulates glucagon secretion in pancreatic α-cells"*
**作者**: Hasegawa Y, et al.
**摘要**: 通过免疫沉淀和染色质免疫共沉淀(ChIP)实验，研究证实KLF15抗体可特异性识别胰岛α细胞中的KLF15蛋白，揭示其通过调控下游靶基因抑制胰高血糖素分泌，影响血糖稳态。
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3. **文献名称**: *"KLF15 suppresses cardiac fibrosis and inflammation by targeting TCF21 in diabetic cardiomyopathy"*
**作者**: Wang B, et al.
**摘要**: 该研究使用KLF15抗体验证了其在糖尿病心肌病模型中的表达下调，发现KLF15通过抑制TCF21介导的纤维化和炎症反应，保护心脏功能，为治疗糖尿病相关心脏病变提供新靶点。
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**备注**：以上文献为示例，实际引用时需核实具体期刊名称、年份及作者信息。建议通过PubMed或Web of Science以“KLF15 antibody”或“KLF15 function”为关键词检索最新研究。
**Background of KLF15 Antibody**
The Krüppel-like factor 15 (KLF15) is a transcription factor belonging to the Krüppel-like family, characterized by zinc finger DNA-binding domains. KLF15 plays a critical role in regulating cellular processes such as metabolism, differentiation, and circadian rhythm. It is expressed in tissues like liver, muscle, adipose, and kidney, where it modulates genes involved in glucose homeostasis, lipid metabolism, and nitrogen balance. Dysregulation of KLF15 has been linked to metabolic disorders (e.g., diabetes, obesity), cardiovascular diseases, and fibrosis.
KLF15 antibodies are essential tools for detecting and quantifying KLF15 protein levels in research. They enable investigations into its expression patterns, subcellular localization, and interaction partners via techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). Specificity and validation (e.g., knockout controls) are crucial for reliable results, as KLF15 shares structural homology with other KLF family members.
Research using KLF15 antibodies has uncovered its role in circadian metabolic rhythms, its suppression of pathological cardiac hypertrophy, and its interplay with signaling pathways like AMPK and mTOR. These findings highlight KLF15 as a potential therapeutic target. Commercial KLF15 antibodies are typically developed in hosts like rabbits or mice, targeting unique epitopes to ensure specificity. Their application continues to advance understanding of metabolic and degenerative diseases.
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