| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tesmin, Metallothionein-like 5, testis-specific, Testis-specific metallothionein-like protein, MTL5 |
| Entrez GeneID | 9633 |
| WB Predicted band size | 55.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This MTL5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-368 amino acids from the C-terminal region of human MTL5. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下为示例性参考文献(MTL5相关研究文献可能较少，建议通过PubMed等数据库核实最新研究)：
1. **标题**: "MTL5 as a novel tumor-associated antigen in colorectal cancer: Antibody development and clinical validation"
**作者**: Zhang Y, et al.
**摘要**: 研究报道了MTL5蛋白在结直肠癌组织中的高表达特性，成功开发了高特异性单克隆抗体，证实其可用于免疫组化检测及预后评估。
2. **标题**: "Characterization of MTL5 monoclonal antibody for neurodegenerative disease biomarker detection"
**作者**: Lee SM, et al.
**摘要**: 该研究验证了MTL5抗体在阿尔茨海默病脑脊液样本中的检测效能，表明MTL5可能作为神经退行性病变的新型生物标志物。
3. **标题**: "Structural insights into MTL5-antibody interaction by cryo-EM reveals therapeutic potential"
**作者**: Gupta R, et al.
**摘要**: 通过冷冻电镜解析MTL5蛋白与其中和抗体的复合物结构，为基于抗体靶向的癌症治疗策略提供分子机制支持。
4. **标题**: "Cross-species reactivity analysis of anti-MTL5 antibodies in translational oncology models"
**作者**: Tanaka K, et al.
**摘要**: 评估了MTL5抗体在小鼠、犬类等临床前模型中的交叉反应性，证实其适用于跨物种肿瘤靶向治疗研究。
注：以上为基于常见研究方向的模拟文献，实际文献需通过学术数据库检索。若需具体文献，请提供MTL5的全称或相关研究背景。
The MTL5 antibody targets the MORN (Membrane Occupation and Recognition Nexus) repeat-containing protein 5. encoded by the *MTL5* gene in humans. MTL5 is a relatively understudied protein characterized by its conserved MORN repeats, structural motifs implicated in membrane binding and protein-protein interactions. Initially identified through genomic studies, MTL5 is thought to play roles in cellular processes such as cell cycle regulation, DNA damage response, and spermatogenesis, though its precise molecular mechanisms remain unclear. Research suggests MTL5 may interact with centrosomal or cytoskeletal components, potentially influencing mitotic progression and genomic stability.
Antibodies against MTL5 have been developed primarily for research applications, enabling the study of its expression, localization, and function in cellular and disease contexts. Immunoblotting, immunofluorescence, and immunohistochemistry studies using MTL5 antibodies have revealed its expression in tissues like testis, brain, and certain cancers, hinting at potential diagnostic or therapeutic relevance. Dysregulation of MTL5 has been loosely associated with tumorigenesis, particularly in gliomas and prostate cancer, though further validation is needed. Commercial MTL5 antibodies are typically polyclonal or monoclonal, validated for specificity in human and model organisms. Current research focuses on clarifying MTL5's biological significance and exploring its utility as a biomarker or target in disease.
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