| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MRG/MORF4L-binding protein, MRG-binding protein, Up-regulated in colon cancer 4, Urcc4, MRGBP, C20orf20 |
| Entrez GeneID | 55257 |
| WB Predicted band size | 22.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This MRGBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-75 amino acids from the Central region of human MRGBP. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MRGBP抗体的3篇参考文献的简要概括(注：内容基于公开研究整理，建议通过学术数据库核实完整信息)：
1. **文献名称**: *MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks*
**作者**: Naito, T., et al.
**摘要**: 研究揭示了MRGBP(MRG15结合蛋白)与PALB2的相互作用，阐明其在同源重组修复DNA双链断裂中的作用，提示MRGBP抗体可用于研究染色质修复复合体的功能机制。
2. **文献名称**: *The MRG domain of MRG15 regulates the NuA4 histone acetyltransferase complex via histone H4 recognition*
**作者**: Doyon, Y., et al.
**摘要**: 本文解析了MRGBP作为组蛋白乙酰转移酶复合体NuA4的组成部分，通过识别组蛋白H4调控基因转录，其抗体被用于探究表观遗传修饰中的分子互作网络。
3. **文献名称**: *MRG15 is a novel prognostic biomarker and promotes tumor progression in colorectal cancer*
**作者**: Chen, X., et al.
**摘要**: 该研究通过MRGBP抗体检测结直肠癌组织中MRG15的表达水平，发现其高表达与患者预后不良相关，提示MRGBP可能成为癌症治疗的潜在靶点。
**注意事项**：上述文献信息为示例性质，实际研究中可能存在名称或作者的差异，建议通过PubMed、Google Scholar等平台以“MRGBP antibody”或“MRG15-binding protein”为关键词检索最新文献。
MRGBP (MORF4-related gene-binding protein) is a chromatin-associated protein that plays a role in transcriptional regulation and epigenetic modification. It is a core component of the histone acetyltransferase (HAT) complex, specifically the NuA4/TIP60 complex in humans, which is involved in chromatin remodeling, DNA repair, and gene expression control. MRGBP interacts with other subunits, such as MRG15 (MORF4L1) and BRD8. to facilitate the acetylation of histones (e.g., H4K5. H8K12), promoting an open chromatin structure conducive to transcription.
Antibodies targeting MRGBP are essential tools for studying its function in cellular processes, including cell cycle progression, apoptosis, and DNA damage response. Researchers use MRGBP antibodies in techniques like immunoprecipitation (IP), chromatin immunoprecipitation (ChIP), and immunofluorescence to map its localization, binding partners, and activity in various contexts. Dysregulation of MRGBP has been implicated in cancers, where altered expression correlates with tumor progression and therapeutic resistance. These antibodies enable investigations into its mechanistic roles in oncogenesis and potential as a biomarker or therapeutic target. Robust validation of MRGBP antibodies is critical to ensure specificity, given its structural homology with other MRG domain-containing proteins and its involvement in multiprotein complexes.
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