| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Meiotic nuclear division protein 1 homolog, MND1 {ECO:0000312|EMBL:EAX049641} |
| Entrez GeneID | 84057 |
| WB Predicted band size | 23.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This MND1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 174-200 amino acids from the C-terminal region of human MND1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MND1抗体的3篇参考文献示例(注：文献为模拟示例，非真实存在)：
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1. **文献名称**: *MND1 Antibody Characterization in Meiotic Chromosome Synapsis*
**作者**: Smith A, et al.
**摘要**: 研究通过制备多克隆抗体，验证MND1蛋白在小鼠减数分裂粗线期生殖细胞中的定位。抗体通过免疫荧光和Western blot证实特异性，揭示MND1在联会复合体形成中的关键作用。
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2. **文献名称**: *Role of MND1 in Human Spermatogenesis: Insights from Antibody-Based Profiling*
**作者**: Chen L, et al.
**摘要**: 使用商业化MND1抗体分析人类睾丸组织，发现MND1在精母细胞中高表达，其表达水平与不育症患者精子发生停滞相关，提示其作为生殖障碍的生物标志物潜力。
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3. **文献名称**: *Development of a Monoclonal Antibody for Detecting MND1 in Cancer Cell Lines*
**作者**: Tanaka K, et al.
**摘要**: 开发了一种新型单克隆抗体，用于检测多种癌细胞系中MND1的异常表达。研究证实MND1在卵巢癌中上调，并与基因组不稳定性相关，为癌症靶向研究提供工具。
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(如需真实文献，建议通过PubMed或Google Scholar搜索关键词“MND1 antibody”或“MND1 protein function”。)
The MND1 (Meiotic Nuclear Division 1) antibody is a crucial tool for studying meiosis, a specialized cell division process essential for gamete formation. MND1 encodes a protein that plays a pivotal role in homologous chromosome pairing, synapsis, and DNA double-strand break repair during meiotic prophase I. It interacts with HOP2 (Homolog Pairing 2) to form a heterodimeric complex, which stabilizes recombination intermediates and promotes homologous recombination by facilitating strand invasion. Dysregulation of MND1 is linked to meiotic defects, infertility, and genomic instability.
The MND1 antibody is widely used in reproductive biology, developmental studies, and cancer research to investigate meiotic mechanisms, germ cell development, and chromosomal abnormalities. It enables the detection and localization of MND1 protein via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Researchers also utilize it to explore MND1’s role in somatic DNA repair pathways and its potential implications in cancer, where aberrant recombination may drive genomic alterations.
Validated in knockout models or siRNA-treated cells, high-quality MND1 antibodies ensure specificity, aiding in functional studies and diagnostic applications. Its utility extends to elucidating molecular pathways underlying infertility disorders and developing therapeutic strategies targeting meiotic proteins. Overall, the MND1 antibody serves as a vital reagent for advancing our understanding of genome stability and reproductive health.
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