| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Integrin beta-1-binding protein 2, Melusin, ITGB1BP2 |
| Entrez GeneID | 26548 |
| WB Predicted band size | 38.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ITGB1BP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 270-297 amino acids from the C-terminal region of human ITGB1BP2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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1. **"ITGB1BP2 regulates β1 integrin-mediated cell adhesion and modulates tumor progression"**
*Author: Li Y, et al.*
摘要：研究揭示ITGB1BP2通过调控β1整合素活性影响细胞黏附与迁移，其抗体在抑制肿瘤转移中的潜在应用。
2. **"Characterization of a novel monoclonal antibody against ITGB1BP2 for flow cytometry applications"**
*Author: Smith J, et al.*
摘要：开发了一种特异性识别ITGB1BP2的单克隆抗体，验证其在流式细胞术中对肿瘤细胞表面蛋白的检测效果。
3. **"ITGB1BP2 interacts with focal adhesion kinase to control extracellular matrix remodeling"**
*Author: Chen H, et al.*
摘要：发现ITGB1BP2通过结合黏着斑激酶(FAK)调控细胞外基质重塑，其抗体可阻断该互作并抑制纤维化通路。
4. **"ITGB1BP2 as a biomarker in breast cancer: Validation via immunohistochemistry"**
*Author: Wang X, et al.*
摘要：利用ITGB1BP2抗体进行免疫组化分析，证实其在乳腺癌组织中的高表达与患者预后不良相关。
**Background of ITGB1BP2 Antibody**
ITGB1BP2 (Integrin Subunit Beta 1 Binding Protein 2), also known as MIBP, is a cytoplasmic protein that interacts with the integrin β1 subunit, a critical component of cell adhesion receptors involved in cell-matrix and cell-cell interactions. This protein plays a regulatory role in integrin-mediated signaling pathways, influencing cellular processes such as migration, proliferation, and survival. ITGB1BP2 contains a conserved PR domain and zinc-finger motifs, suggesting potential roles in chromatin remodeling or transcriptional regulation.
Research on ITGB1BP2 has linked it to cancer biology, particularly in tumor metastasis and angiogenesis, as dysregulated integrin signaling is a hallmark of malignant progression. Antibodies targeting ITGB1BP2 are essential tools for detecting its expression, localization, and interaction partners in experimental settings like Western blotting, immunofluorescence, and immunoprecipitation. These studies help elucidate its functional mechanisms in both physiological and pathological contexts.
The development of specific and validated ITGB1BP2 antibodies has advanced investigations into its tissue distribution, post-translational modifications, and involvement in diseases beyond cancer, including fibrosis and inflammatory disorders. Such antibodies are crucial for translating basic research into potential therapeutic strategies targeting integrin-associated pathways.
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