| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cartilage acidic protein 1, 68 kDa chondrocyte-expressed protein, CEP-68, ASPIC, CRTAC1, ASPIC1, CEP68 |
| Entrez GeneID | 55118 |
| WB Predicted band size | 71.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CRTAC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 130-156 amino acids from the N-terminal region of human CRTAC1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CRTAC1 (N-term)抗体的模拟参考文献示例(基于公开研究概括，非真实文献)：
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1. **文献名称**: *CRTAC1 as a novel biomarker for osteoarthritis: Expression analysis and functional characterization*
**作者**: Smith J, et al.
**摘要**: 本研究通过Western blot和免疫组化技术，利用CRTAC1 (N-term)抗体检测了骨关节炎患者软骨组织中CRTAC1蛋白的表达水平，发现其表达与疾病严重程度呈正相关，提示CRTAC1可能参与软骨退变过程。
2. **文献名称**: *The role of CRTAC1 in extracellular matrix remodeling during chondrocyte differentiation*
**作者**: Lee H, et al.
**摘要**: 研究通过CRTAC1 (N-term)抗体进行免疫荧光染色，揭示CRTAC1在软骨细胞分化过程中调控细胞外基质成分(如胶原Ⅱ)的合成，为软骨再生机制提供了新见解。
3. **文献名称**: *Proteomic identification of CRTAC1 N-terminal fragments in serum of pulmonary fibrosis patients*
**作者**: Garcia R, et al.
**摘要**: 利用CRTAC1 (N-term)抗体对肺纤维化患者血清进行ELISA检测，发现CRTAC1的N端片段水平显著升高，提示其可能作为肺部纤维化的潜在诊断标志物。
4. **文献名称**: *CRTAC1 interacts with β-catenin in Wnt signaling pathway: A structural study*
**作者**: Chen L, et al.
**摘要**: 通过免疫共沉淀(使用CRTAC1 N-term抗体)和质谱分析，证实CRTAC1通过N端结构域与β-catenin结合，参与Wnt信号通路调控，影响骨形成过程。
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**说明**：以上内容为模拟示例，实际文献需通过PubMed、Google Scholar等数据库检索确认。建议使用关键词“CRTAC1 antibody”、“CRTAC1 N-terminal”或结合具体研究领域(如骨关节炎、肺纤维化)进行精准查询。
The CRTAC1 (N-term) antibody targets the N-terminal region of Cartilage Acidic Protein 1 (CRTAC1), a glycoprotein predominantly expressed in chondrocytes and associated with extracellular matrix (ECM) organization. CRTAC1 is implicated in cartilage development, maintenance, and repair, with potential roles in cell adhesion, differentiation, and tissue homeostasis. Its expression is linked to cartilage-related pathologies, including osteoarthritis and skeletal disorders, making it a biomarker of interest in musculoskeletal research.
This antibody is commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect CRTAC1 in biological samples. By specifically binding to the N-terminal epitope, it helps researchers study the protein's expression patterns, localization, and regulatory mechanisms under physiological or disease conditions. The N-terminal region of CRTAC1 is critical for its functional interactions, possibly influencing ECM stability or signaling pathways.
Commercial CRTAC1 (N-term) antibodies are typically validated for specificity and sensitivity across species, particularly human and murine models. Their application supports investigations into cartilage degeneration, regenerative therapies, and biomarker discovery. However, users should optimize experimental conditions (e.g., antigen retrieval for IHC) to account for tissue-specific variations in CRTAC1 expression or post-translational modifications.
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