| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein 589, Stem cell zinc finger protein 1, ZNF589, SZF1 |
| Entrez GeneID | 51385 |
| WB Predicted band size | 41.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZNF589 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 184-210 amino acids from the Central region of human ZNF589. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZNF589抗体的3篇文献示例(注：因文献数据库限制，以下内容为模拟示例，实际文献需通过学术平台检索验证)：
1. **文献名称**：*ZNF589 suppresses tumorigenesis by regulating epigenetic modifiers in lung cancer*
**作者**：Li Y, et al.
**摘要**：研究利用ZNF589抗体通过免疫印迹和免疫组化分析，发现ZNF589在肺癌组织中表达下调，其缺失通过表观遗传修饰促进肿瘤侵袭，提示其抑癌作用。
2. **文献名称**：*Characterization of ZNF589 antibody specificity in neural development*
**作者**：Smith J, et al.
**摘要**：通过免疫荧光和ChIP-seq验证ZNF589抗体的特异性，证明其在胚胎神经发育中调控靶基因表达，为神经分化研究提供工具支持。
3. **文献名称**：*ZNF589 interacts with HPV oncoproteins and predicts cervical cancer prognosis*
**作者**：Wang H, et al.
**摘要**：使用ZNF589抗体进行免疫共沉淀，发现其与HPV E6蛋白互作，低表达患者预后较差，提示其作为宫颈癌生物标志物的潜力。
建议通过 **PubMed/Google Scholar** 检索实际文献，关键词：**"ZNF589 antibody" + "application"**。
ZNF589 antibody is a research tool designed to detect and study the zinc finger protein 589 (ZNF589), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein family. ZNF589 is encoded by the ZNF589 gene in humans and is characterized by multiple C2H2-type zinc finger motifs, which are typically involved in DNA binding and transcriptional regulation. These proteins play roles in chromatin remodeling, gene silencing, and cellular differentiation by recruiting chromatin-modifying complexes through their KRAB domains. While the exact biological functions of ZNF589 remain less characterized compared to other zinc finger proteins, it is believed to participate in tissue-specific gene regulation and may have implications in cancer, neurological disorders, or developmental processes.
The ZNF589 antibody is commonly generated in laboratory animals (e.g., rabbits or mice) using immunogenic peptides or recombinant protein fragments corresponding to specific epitopes of the human ZNF589 protein. It is widely used in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP) to investigate ZNF589's expression patterns, subcellular localization, and molecular interactions. Researchers utilize this antibody to explore its potential roles in disease mechanisms, particularly in cancers where zinc finger proteins often act as tumor suppressors or oncogenes. Validation of the antibody typically includes testing in knockout cell lines or tissues to confirm specificity. Its availability supports ongoing studies into the regulatory networks governed by KRAB-zinc finger proteins in health and disease.
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