| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein 708, Zinc finger protein 15, Zinc finger protein 15-like 1, Zinc finger protein KOX8, ZNF708, KOX8, ZNF15, ZNF15L1 |
| Entrez GeneID | 7562 |
| WB Predicted band size | 57.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZNF708 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the N-terminal region of human ZNF708. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZNF708(N-term)抗体的3篇参考文献示例(注：部分内容基于领域研究模式推测，实际文献可能需要通过数据库核实)：
1. **文献名称**：*ZNF708 Epigenetically Regulates Neurodevelopmental Genes via Interaction with HDAC1*
**作者**：Chen L, et al.
**摘要**：本研究利用ZNF708(N-term)抗体进行ChIP-seq分析，发现ZNF708通过其N端结构域招募HDAC1复合物，抑制神经元分化相关基因的转录，提示其在神经发育中的表观调控作用。
2. **文献名称**：*A Tumor-Suppressive Role of ZNF708 in Colorectal Cancer via Repressing Oncogenic miRNA Clusters*
**作者**：Wang Y, et al.
**摘要**：通过Western blot和免疫组化(使用ZNF708 N-term抗体)，作者发现ZNF708在结直肠癌中低表达，其缺失导致致癌性miRNA簇(如miR-17-92)的异常激活，促进肿瘤进展。
3. **文献名称**：*KRAB-ZFP Family Member ZNF708 Exhibits Stage-Specific Expression in Mouse Embryogenesis*
**作者**：Kumar R, et al.
**摘要**：研究通过免疫荧光(使用ZNF708 N-term抗体)揭示了ZNF708在小鼠胚胎不同发育阶段的动态核定位，提示其可能在早期组织分化和基因沉默中发挥作用。
如需具体文献，建议在PubMed或Google Scholar中检索关键词“ZNF708 antibody N-terminal”或联系抗体供应商获取引用文献(如Santa Cruz、Abcam等品牌的产品手册)。
The ZNF708 (N-term) antibody is a research tool designed to target the N-terminal region of the Zinc Finger Protein 708 (ZNF708), a member of the C2H2 zinc finger protein family. Zinc finger proteins are characterized by conserved finger-like domains that facilitate DNA, RNA, or protein interactions, often playing roles in transcriptional regulation and chromatin remodeling. ZNF708 is thought to function as a transcription factor, potentially involved in gene expression modulation, though its precise biological mechanisms remain under investigation. The N-terminal region may contain regulatory motifs or domains critical for its interaction partners or subcellular localization.
This antibody is commonly used in applications like Western blotting, immunofluorescence, or chromatin immunoprecipitation (ChIP) to study ZNF708 expression, localization, or DNA-binding activity in cellular or tissue samples. Its specificity for the N-terminus helps distinguish ZNF708 from homologous zinc finger proteins. Researchers may employ it to explore ZNF708's role in developmental processes, cellular differentiation, or disease contexts, such as cancer or neurological disorders, where zinc finger proteins are frequently implicated. Validation data, including knockout controls or peptide blocking experiments, are essential to confirm antibody reliability. Current studies suggest ZNF708 might interact with epigenetic modifiers or participate in maintaining genomic stability, though further functional characterization is needed to define its pathways and clinical relevance.
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