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Rabbit Polyclonal METTL7B(N-term) Antibody

  • 中文名： METTL7B (N-term)抗体
  • 别    名： Methyltransferase-like protein 7B, 211-, METTL7B
货号: IPDX31922
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesMethyltransferase-like protein 7B, 211-, METTL7B
Entrez GeneID196410
WB Predicted band size27.8kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenThis METTL7B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-63 amino acids from the N-terminal region of human METTL7B.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于METTL7B(N-term)抗体的3篇参考文献的简要信息：

1. **文献名称**: *METTL7B regulates hepatocellular carcinoma progression through m6A modification*

**作者**: Zhang Y, et al.

**摘要**: 该研究利用METTL7B(N-term)抗体进行Western blot和免疫组化分析，发现METTL7B通过介导m6A修饰促进肝癌细胞增殖和转移，提示其作为潜在治疗靶点。

2. **文献名称**: *Characterization of METTL7B as a lipid metabolism-related methyltransferase in adipocytes*

**作者**: Wang L, et al.

**摘要**: 作者使用METTL7B(N-term)抗体验证脂肪细胞中METTL7B的蛋白表达，证明其通过调控脂质代谢相关基因的甲基化影响脂肪分化。

3. **文献名称**: *Proteomic analysis identifies METTL7B as a novel biomarker in Alzheimer’s disease*

**作者**: Kim S, et al.

**摘要**: 研究通过METTL7B(N-term)抗体的免疫沉淀技术，发现METTL7B在阿尔茨海默病患者脑组织中异常表达，并与tau蛋白病理过程相关。

(注：上述文献为虚拟示例，实际文献需通过PubMed或Google Scholar检索确认。)

背景信息

The METTL7B (N-term) antibody is designed to target the N-terminal region of methyltransferase-like protein 7B (METTL7B), a member of the methyltransferase enzyme family. METTL7B is a poorly characterized protein implicated in various cellular processes, including lipid metabolism, cellular differentiation, and response to oxidative stress. Emerging studies suggest its potential role in cancer progression, neurological disorders, and metabolic diseases, though its precise molecular mechanisms remain unclear. The N-terminal region of METTL7B contains conserved structural motifs critical for its putative methyltransferase activity or protein-protein interactions. This antibody is commonly used in research applications such as Western blotting, immunohistochemistry, and immunofluorescence to detect endogenous METTL7B expression, assess its tissue-specific distribution, and explore its functional interactions. Its specificity for the N-terminal epitope helps distinguish METTL7B from homologous family members like METTL7A, minimizing cross-reactivity. Studies utilizing this antibody have reported METTL7B localization in the endoplasmic reticulum and cytoplasm, with variable expression levels observed across tissues, including liver, brain, and reproductive organs. Ongoing research aims to clarify METTL7B's substrate specificity, regulatory pathways, and therapeutic relevance in disease contexts.

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