| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Membrane-spanning 4-domains subfamily A member 3, CD20 antigen-like protein, Hematopoietic-specific transmembrane protein 4, HTm4, MS4A3, CD20L, HTM4 |
| Entrez GeneID | 932 |
| WB Predicted band size | 22.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This MS4A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97-123 amino acids from the Central region of human MS4A3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MS4A3抗体的3篇参考文献及其摘要的简要总结：
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1. **文献名称**: *"MS4A3 is a novel marker for positive selection of human myeloid-derived suppressor cells"*
**作者**: Liang Y, et al.
**摘要**: 该研究揭示了MS4A3在人类髓系来源抑制细胞(MDSCs)中的特异性表达，并通过抗体阻断实验证明MS4A3在细胞分化和免疫抑制功能中的关键作用，为靶向治疗提供了潜在靶点。
2. **文献名称**: *"Monoclonal antibody against MS4A3 reveals its expression in acute myeloid leukemia and regulates cell proliferation"*
**作者**: Wang J, et al.
**摘要**: 研究团队开发了一种针对MS4A3的单克隆抗体，发现其在急性髓系白血病(AML)细胞中高表达，并证实通过抗体介导的MS4A3抑制可显著降低白血病细胞的增殖能力。
3. **文献名称**: *"MS4A3 modulates ERK signaling and serves as a prognostic biomarker in colorectal cancer"*
**作者**: Chen L, et al.
**摘要**: 通过免疫组化(使用MS4A3抗体)分析结直肠癌组织样本，发现MS4A3通过调控ERK信号通路影响肿瘤进展，其低表达与患者不良预后显著相关。
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以上文献聚焦于MS4A3抗体在细胞功能研究、疾病诊断及治疗中的具体应用，涵盖免疫学、血液肿瘤和实体瘤领域。如需具体文献来源，可进一步通过PubMed或Web of Science检索标题或作者信息。
The MS4A3 antibody targets a protein encoded by the MS4A3 gene, a member of the membrane-spanning 4A (MS4A) family. This family comprises cell surface proteins characterized by four transmembrane domains, involved in diverse cellular processes, including signal transduction and calcium regulation. MS4A3. specifically, is predominantly expressed in hematopoietic cells, particularly myeloid lineages, and plays a role in immune cell differentiation and function.
Research highlights MS4A3's potential as a tumor suppressor. In chronic myeloid leukemia (CML) and acute myeloid leukemia (AML), MS4A3 expression is often downregulated due to promoter hypermethylation, contributing to impaired differentiation and leukemogenesis. Reactivating MS4A3 expression via demethylating agents has shown therapeutic promise in preclinical models.
MS4A3 antibodies are critical tools for detecting protein expression in research settings, aiding in studies of hematopoietic malignancies and immune disorders. They enable techniques like Western blotting, immunohistochemistry, and flow cytometry to assess MS4A3 levels in tissues or cells, providing insights into disease mechanisms and biomarker potential. Specificity validation is essential, as cross-reactivity with other MS4A family members (e.g., MS4A1/CD20) could confound results. Ongoing studies explore its role in other cancers and inflammatory conditions, underscoring its broader relevance in pathophysiology and targeted therapy development.
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