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Mouse Monoclonal ARSA Antibody

  • 中文名: ARSA抗体
  • 别    名: Arylsulfatase A, ASA, Cerebroside-sulfatase, Arylsulfatase A component B, Arylsulfatase A component C, ARSA
货号: IPDX31914
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 1/500-1/4000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesArylsulfatase A, ASA, Cerebroside-sulfatase, Arylsulfatase A component B, Arylsulfatase A component C, ARSA
Entrez GeneID410
WB Predicted band size53.6kDa
Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis ARSA antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 408-439 amino acids from the C-terminal region of human ARSA.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于ARSA抗体的3篇示例参考文献(注:以下文献信息为模拟示例,实际文献请通过学术数据库查询):

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1. **文献名称**:*Monoclonal Antibodies Against Arylsulfatase A: A Tool for Diagnosing Metachromatic Leukodystrophy*

**作者**:Smith J, et al.

**摘要**:本研究开发了一种针对ARSA酶的单克隆抗体,用于检测患者细胞中ARSA的活性缺失。通过免疫分析法,该抗体能有效区分健康个体与异染性脑白质营养不良(MLD)患者,为早期诊断提供了高特异性工具。

2. **文献名称**:*Autoantibodies to Arylsulfatase A in Neurological Disorders: Pathological Implications*

**作者**:Lee S, et al.

**摘要**:文章探讨了ARSA自身抗体在多发性硬化症等神经疾病患者中的存在。研究发现,部分患者血清中ARSA抗体水平升高可能干扰酶的正常功能,提示其在神经退行性病变中的潜在作用。

3. **文献名称**:*Enzyme Replacement Therapy for MLD: Enhancing Efficacy via Antibody-Mediated Targeting*

**作者**:Garcia-Ramos M, et al.

**摘要**:该研究利用ARSA特异性抗体修饰重组酶制剂,提高其在细胞内的靶向递送效率。实验显示,抗体介导的酶替代疗法可显著增强ARSA在脑组织中的活性,为MLD治疗提供了新策略。

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如需具体文献,建议通过PubMed、Web of Science等平台检索关键词(如“ARSA antibody”“Arylsulfatase A antibody”“MLD diagnosis”)获取最新研究。

背景信息

ARSA (Arylsulfatase A) antibodies are tools used to detect and study the ARSA enzyme, a lysosomal protein encoded by the *ARSA* gene. ARSA plays a critical role in catalyzing the hydrolysis of sulfatides, a type of sulfated glycolipid, by removing sulfate groups. Deficiency in ARSA activity due to genetic mutations leads to metachromatic leukodystrophy (MLD), a rare autosomal recessive lysosomal storage disorder characterized by sulfatide accumulation, progressive demyelination, and severe neurological deterioration. ARSA antibodies are essential in research and diagnostics to quantify enzyme levels, assess protein expression in tissues or cell cultures, and confirm MLD diagnoses through immunohistochemistry, Western blotting, or ELISA. They also aid in studying disease mechanisms, evaluating experimental therapies (e.g., enzyme replacement, gene therapy), and monitoring therapeutic efficacy. Additionally, ARSA antibodies help distinguish MLD from other neurodegenerative disorders with overlapping symptoms. Their specificity enables precise localization of ARSA in cellular compartments, contributing to insights into lysosomal biology and pathology. As MLD lacks a cure, early detection via ARSA antibody-based assays remains vital for palliative care and emerging treatment trials.

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