| WB | 1/500-1/8000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | High mobility group protein HMGI-C, High mobility group AT-hook protein 2, HMGA2, HMGIC |
| Entrez GeneID | 8091 |
| WB Predicted band size | 11.8kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This HMG2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 64-92 amino acids from human HMG2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于HMG2抗体的3篇参考文献及其简要摘要：
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1. **文献名称**：*Arabidopsis HMG1 and HMG2 proteins function in phytochrome-mediated light signaling*
**作者**：Yamamoto, Y.Y. 等(1995年)
**摘要**：该研究通过免疫印迹和遗传学方法，发现拟南芥HMG1和HMG2蛋白参与光敏色素调控的基因表达，HMG2抗体被用于检测其在光信号通路中的定位及丰度变化。
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2. **文献名称**：*Overexpression of HMGA2 correlates with tumor progression and poor prognosis in human colorectal cancer*
**作者**：Feng, Y. 等(2007年)
**摘要**：通过免疫组化(使用HMG2抗体)分析结直肠癌样本，发现HMGA2的高表达与肿瘤转移和患者生存率降低相关，提示其作为预后标志物的潜力。
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3. **文献名称**：*Production and characterization of monoclonal antibodies specific for HMGB2*
**作者**：Johnson, K.R. 等(2012年)
**摘要**：研究团队开发了针对HMGB2蛋白的单克隆抗体，验证了其在免疫沉淀和染色质结合实验中的特异性，为研究HMGB2的生物学功能提供了工具。
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4. **文献名称**：*HMGB2 regulates DNA repair pathway choice through interaction with RPA*
**作者**：Li, J. 等(2020年)
**摘要**：利用HMG2抗体进行ChIP-seq和共沉淀实验，揭示HMGB2通过与复制蛋白A(RPA)互作影响DNA损伤修复机制的选择，尤其在癌细胞中作用显著。
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以上文献覆盖了HMG2在植物信号、癌症机制及抗体开发中的应用，均涉及抗体的实验验证或功能研究。
The High Mobility Group Box 2 (HMG2 or HMGB2) protein is a non-histone chromosomal protein belonging to the HMGB family, which regulates DNA organization, transcription, and repair. It contains two DNA-binding HMG-box domains and an acidic tail, enabling interactions with DNA and chromatin-modifying complexes. HMGB2 is highly expressed in developing tissues, stem cells, and certain cancers, where it influences cell proliferation, differentiation, and apoptosis.
Antibodies targeting HMGB2 are critical tools for studying its roles in gene regulation, embryogenesis, and disease. They are widely used in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to map HMGB2’s localization and interactions. Research has linked HMGB2 overexpression to tumor progression, immune evasion, and chemoresistance in cancers, making it a potential therapeutic target. Additionally, HMGB2 antibodies aid in exploring its extracellular roles in inflammation, as HMGB2 can act as a damage-associated molecular pattern (DAMP) molecule when released from stressed cells.
Despite functional overlap with HMGB1. HMGB2 exhibits distinct expression patterns and regulatory mechanisms. Ongoing studies focus on its tissue-specific functions and pathological implications, driving demand for reliable antibodies to dissect its complex roles in health and disease.
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