| WB | 1/500-1/8000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | C-reactive protein, C-reactive protein(1-205), CRP, PTX1 |
| Entrez GeneID | 1401 |
| WB Predicted band size | 25.0kDa |
| Host/Isotype | Mouse IgG3 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This CRP antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 194-221 amino acids from human CRP. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与CRP抗体相关的研究文献概览：
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1. **文献名称**：*C-reactive protein and the acute phase response*
**作者**：Pepys, M.B., & Hirschfield, G.M.
**摘要**：经典综述，阐述CRP在炎症反应中的生物学功能及其抗体在检测中的特异性应用，强调CRP作为炎症标志物的临床价值。
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2. **文献名称**：*High-sensitivity C-reactive protein: clinical implications*
**作者**：Ridker, P.M.
**摘要**：探讨高敏CRP(hs-CRP)检测中抗体的优化策略，及其在心血管疾病风险评估中的突破性应用，证明抗体灵敏度对检测结果的影响。
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3. **文献名称**：*Monoclonal antibodies against C-reactive protein for targeted inflammation imaging*
**作者**：Devaraj, S., et al.
**摘要**：报道一种新型单克隆抗体的开发，用于CRP靶向分子成像，验证其在动脉粥样硬化等慢性炎症疾病可视化诊断中的潜力。
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注：以上文献为示例，实际引用时需核对具体来源及发表年份。
C-reactive protein (CRP) antibodies are essential tools in detecting and quantifying CRP, a key acute-phase protein produced by the liver in response to inflammation, infection, or tissue injury. Discovered in 1930 by Tillet and Francis, CRP binds to phosphocholine on pathogens and damaged cells, activating the complement system and promoting phagocytosis. Its rapid rise (within hours) and short half-life make it a sensitive biomarker for monitoring inflammatory conditions.
CRP antibodies, typically monoclonal or polyclonal, are designed to specifically target CRP epitopes. Monoclonal antibodies offer high specificity, minimizing cross-reactivity, while polyclonal antibodies may enhance detection sensitivity. These antibodies underpin diagnostic assays like ELISA, immunoturbidimetry, and lateral flow tests, enabling CRP quantification in clinical settings. Elevated CRP levels correlate with bacterial infections, autoimmune diseases (e.g., rheumatoid arthritis), and cardiovascular risks (hs-CRP assays assess low-level inflammation linked to atherosclerosis).
Therapeutic applications include tracking antibiotic efficacy or disease activity in chronic inflammation. Challenges persist in standardizing assays due to CRP's structural variations (e.g., pentameric vs. monomeric forms) and pre-analytical factors. Nonetheless, CRP antibodies remain indispensable in research and diagnostics, bridging insights into immune responses and guiding clinical decisions.
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