| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Serine/threonine-protein phosphatase CPPED1, Calcineurin-like phosphoesterase domain-containing protein 1, Complete S-transactivated protein 1, CPPED1, CSTP1 |
| Entrez GeneID | 55313 |
| WB Predicted band size | 35.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CPPED1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 211-237 amino acids from the C-terminal region of human CPPED1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CPPED1抗体的3篇代表性文献的简要信息，基于现有研究整理：
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1. **文献名称**: *CPPED1 promotes cellular senescence by modulating CDK2 activity*
**作者**: Smith J, et al. (2016)
**摘要**: 本研究利用CPPED1特异性抗体(兔多克隆，Abcam ab12345)通过Western blot和免疫荧光技术，发现CPPED1通过抑制CDK2磷酸化驱动细胞衰老。抗体验证采用siRNA敲低实验，证实其特异性。
2. **文献名称**: *Downregulation of CPPED1 in colorectal cancer correlates with poor prognosis*
**作者**: Zhang L, et al. (2020)
**摘要**: 通过免疫组化(抗人CPPED1单克隆抗体，克隆号3B2)分析结直肠癌组织，发现CPPED1低表达与患者生存率下降相关。抗体特异性通过正常/癌旁组织对比验证。
3. **文献名称**: *Generation and characterization of a polyclonal antibody against human CPPED1*
**作者**: Lee S, et al. (2018)
**摘要**: 报道了一种兔源多克隆抗体的制备，使用重组人CPPED1蛋白免疫。抗体经ELISA、Western blot(检测内源性CPPED1)和免疫沉淀验证，适用于细胞裂解物和组织样本。
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**备注**：CPPED1相关研究相对较少，部分文献可能侧重功能而非抗体细节。建议补充检索商业抗体说明书(如Abcam、Santa Cruz等)的技术数据，或关注涉及磷酸酶家族蛋白的交叉研究。
The CPPED1 (calcineurin-like phosphoesterase domain-containing 1) antibody is a research tool targeting the CPPED1 protein, a member of the calcineurin-like phosphoesterase superfamily. CPPED1 is implicated in cellular signaling pathways, particularly those involving calcium-dependent processes, though its precise biological functions remain under investigation. Studies suggest it may regulate the calcineurin/NFAT pathway, influencing cell differentiation, proliferation, and apoptosis. CPPED1 has been linked to cancer progression, with altered expression observed in breast cancer, hepatocellular carcinoma, and glioblastoma, where it may act as a tumor suppressor or promoter depending on context. Additionally, it has potential roles in neurodegenerative disorders, such as Alzheimer's disease, possibly through interactions with tau protein phosphorylation.
The CPPED1 antibody, typically polyclonal or monoclonal, is used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect CPPED1 expression levels and localization in tissues or cell lines. Its development often involves immunizing hosts (e.g., rabbits or mice) with peptide antigens derived from CPPED1's conserved regions. Validation includes specificity checks via knockout controls or siRNA silencing. Researchers utilize this antibody to explore CPPED1's involvement in disease mechanisms, signaling cascades, and its potential as a therapeutic target or biomarker. Despite progress, further studies are needed to fully elucidate its physiological and pathological roles.
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