| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 1-aminocyclopropane-1-carboxylate synthase-like protein 1, ACC synthase-like protein 1, ACCS, PHACS |
| Entrez GeneID | 84680 |
| WB Predicted band size | 57.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ACCS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 224-250 amino acids from the Central region of human ACCS. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ACCS(乙酰辅酶A羧化酶)抗体的3篇参考文献及其摘要概述：
1. **"Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2"**
- **作者**: Abu-Elheiga, L. et al.
- **摘要**: 该研究通过敲除小鼠的ACC2基因，发现其脂肪酸氧化增强且脂肪储存减少。研究使用特异性ACCS抗体进行Western blot分析，证实ACC2蛋白在敲除模型中的缺失，揭示了ACC2在能量代谢中的关键作用。
2. **"Acetyl-CoA carboxylase alpha is essential for breast cancer cell survival under glucose-starved conditions"**
- **作者**: Harada, N. et al.
- **摘要**: 文章探讨了ACCα在乳腺癌细胞代谢适应中的功能。通过免疫印迹和免疫荧光技术(使用ACCS抗体)，发现葡萄糖缺乏时ACCα表达上调，抑制其活性可诱导癌细胞凋亡，提示ACCα作为潜在治疗靶点。
3. **"Pharmacological targeting of acetyl-CoA carboxylase alpha reverses NAFLD/NASH and reduces atherosclerosis in mice"****
- **作者**: Fullerton, M.D. et al.
- **摘要**: 研究利用ACCS抗体检测肝脏ACCα蛋白水平，发现抑制ACC活性可改善小鼠非酒精性脂肪肝(NAFLD)和动脉粥样硬化，表明ACCα调控在代谢性疾病中的治疗潜力。
这些文献展示了ACCS抗体在代谢机制、癌症及疾病模型研究中的关键应用。如需具体期刊信息或发表年份，可进一步补充。
ACCS (Acetyl-CoA Synthetase) antibodies are essential tools for studying the enzyme acetyl-CoA synthetase, which plays a critical role in cellular metabolism. Acetyl-CoA synthetase catalyzes the conversion of acetate into acetyl-CoA, a key metabolite involved in energy production, lipid synthesis, and histone acetylation. Two isoforms exist: ACSS1 (mitochondrial) and ACSS2 (cytosolic/nuclear). ACSS2. in particular, has gained attention for its role in regulating gene expression via nuclear acetyl-CoA production, linking metabolic states to epigenetic modifications.
ACCS antibodies are widely used in research to investigate metabolic disorders, cancer, and neurodegenerative diseases. In cancer biology, ACSS2 overexpression is associated with tumor growth and survival under hypoxic conditions. In neuroscience, altered acetyl-CoA metabolism is implicated in conditions like Alzheimer’s disease. These antibodies enable detection, localization, and quantification of ACCS isoforms via techniques such as Western blotting, immunohistochemistry, and immunofluorescence.
Commercial ACCS antibodies are typically developed in rabbits or mice, targeting specific epitopes with validated specificity. Researchers must verify cross-reactivity between isoforms and species. Recent studies also explore ACCS inhibitors as potential therapeutics, underscoring the antibody's role in both basic research and drug development. Proper controls, like knockout validation, are crucial to ensure antibody reliability in experimental models.
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