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Rabbit Polyclonal ZNF695 Antibody

  • 中文名: ZNF695抗体
  • 别    名: Zinc finger protein 695, Zinc finger protein SBZF3, ZNF695
货号: IPDX31895
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesZinc finger protein 695, Zinc finger protein SBZF3, ZNF695
Entrez GeneID57116
WB Predicted band size60.1kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis ZNF695 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 244-269 amino acids from the Central region of human ZNF695.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于ZNF695抗体的虚构参考文献示例(实际文献需通过学术数据库验证):

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1. **《ZNF695在乳腺癌中的表达及临床意义》**

*作者:Smith A, et al. (2020)*

摘要:本研究通过免疫组化(使用ZNF695特异性抗体)分析乳腺癌组织样本,发现ZNF695蛋白高表达与肿瘤侵袭性及患者预后不良显著相关,提示其可能作为乳腺癌潜在生物标志物。

2. **《ZNF695通过调控Wnt信号通路促进肝癌进展》**

*作者:Chen L, et al. (2018)*

摘要:利用ZNF695抗体进行Western blot和免疫荧光实验,证实ZNF695在肝癌细胞中过表达,并通过激活Wnt/β-catenin通路增强肿瘤细胞增殖和转移能力。

3. **《ZNF695在干细胞分化中的表观遗传调控作用》**

*作者:Lee J, et al. (2021)*

摘要:研究通过ChIP-seq(使用ZNF695抗体)揭示ZNF695结合于特定基因启动子区域,调控多能干细胞向神经谱系分化的关键过程,表明其参与表观遗传修饰。

4. **《ZNF695作为胶质瘤诊断标志物的验证研究》**

*作者:Zhang Y, et al. (2019)*

摘要:通过ELISA和免疫组织化学(ZNF695抗体)检测发现,胶质瘤患者血清及组织中ZNF695水平显著升高,提示其可能作为新型诊断或治疗靶点。

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**注意**:以上内容为示例,非真实文献。建议通过PubMed、Web of Science或Google Scholar检索实际研究。

背景信息

The ZNF695 antibody is a crucial tool for studying the ZNF695 protein, a member of the zinc finger protein (ZFP) family characterized by C2H2-type zinc finger domains. ZNF695 is implicated in transcriptional regulation, chromatin remodeling, and cellular differentiation, often through its interaction with DNA or other proteins. Its expression has been linked to various cancers, including hepatocellular carcinoma and leukemia, where it may act as an oncogene or tumor suppressor depending on context. Researchers use ZNF695 antibodies primarily in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP) to detect protein expression levels, subcellular localization, and DNA-binding activity. These antibodies are typically raised in hosts like rabbits or mice, with validation steps including knockout cell line controls and peptide-blocking assays to confirm specificity. Commercial ZNF695 antibodies often cite applications in cancer biology, epigenetic studies, and developmental research. However, users should verify antibody performance for their specific experimental conditions, as off-target binding remains a concern with zinc finger proteins due to structural similarities across family members. Recent studies also explore ZNF695's role in viral defense mechanisms and stem cell pluripotency, expanding its relevance in biomedical research.

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