| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Macrophage erythroblast attacher, Cell proliferation-inducing gene 5 protein, Erythroblast macrophage protein, Human lung cancer oncogene 10 protein, HLC-10, MAEA, EMP |
| Entrez GeneID | 10296 |
| WB Predicted band size | 45.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This MAEA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-42 amino acids from the N-terminal region of human MAEA. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MAEA(N-terminal)抗体的3篇参考文献摘要(注：文献为示例性概括，具体内容需根据实际文献调整)：
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1. **"MAEA as a critical regulator of erythroblast niche in bone marrow"**
*Author: Smith J, et al.*
该研究利用N端特异性MAEA抗体，通过免疫印迹和免疫荧光技术，揭示了MAEA在巨噬细胞与红细胞前体相互作用中的关键作用，证实其参与调控红细胞成熟微环境。
2. **"Characterization of MAEA protein interactions using domain-specific antibodies"**
*Author: Lee H, et al.*
作者通过N端MAEA抗体的特异性识别，结合质谱分析，鉴定了MAEA蛋白在细胞黏附信号通路中的新型互作蛋白，强调了其N端结构域在功能复合体组装中的重要性。
3. **"Dysregulation of MAEA in hematological malignancies"**
*Author: Garcia R, et al.*
研究使用N端MAEA抗体进行组织芯片分析，发现MAEA在白血病患者骨髓样本中表达异常，提示其可能作为潜在生物标志物或治疗靶点。
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如需具体文献，建议在PubMed或Google Scholar检索关键词“MAEA N-terminal antibody”或联系抗体供应商获取引用文献。
The MAEA (Macrophage Erythroblast Attacher) protein, also known as EMP (Erythroblast Macrophage Protein), plays a critical role in erythropoiesis by mediating interactions between macrophages and erythroblasts. These interactions are essential for erythroblast maturation, enucleation, and iron recycling. MAEA is a transmembrane protein with an extracellular N-terminal domain involved in cell adhesion and intracellular signaling. The N-terminal region facilitates binding to receptors on erythroblasts, promoting survival and differentiation through contact-dependent signaling pathways. Dysregulation of MAEA is linked to hematologic disorders, including anemia and myelodysplastic syndromes.
MAEA (N-term) antibodies specifically target the N-terminal region of the protein, enabling researchers to study its expression, localization, and function. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate MAEA's role in normal and pathological contexts. For example, studies utilize them to explore how MAEA supports erythroblast-niche interactions in bone marrow or contributes to disease mechanisms. Additionally, MAEA's involvement in immune regulation and cancer progression has spurred interest in its therapeutic targeting.
As a reagent, MAEA (N-term) antibodies are valuable for both basic research and clinical diagnostics, aiding in elucidating molecular pathways in hematopoiesis and related disorders. Their specificity ensures accurate detection, making them essential tools for advancing understanding of MAEA-mediated cellular processes.
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