| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | DnaJ homolog subfamily B member 9, Endoplasmic reticulum DNA J domain-containing protein 4, ER-resident protein ERdj4, ERdj4, Microvascular endothelial differentiation gene 1 protein, Mdg-1, DNAJB9, MDG1 |
| Entrez GeneID | 4189 |
| WB Predicted band size | 25.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This DNAJB9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-69 amino acids from the N-terminal region of human DNAJB9. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于DNAJB9 (N-term)抗体的参考文献及其摘要概括：
1. **文献名称**：*DNAJB9 is a specific diagnostic marker for fibrillary glomerulonephritis*
**作者**：Larsen CP, et al.
**摘要**：该研究验证了DNAJB9抗体在诊断纤维样肾小球肾炎(FGN)中的特异性，发现其N端抗体在免疫组化中能选择性标记FGN患者肾组织，而其他肾病类型无此反应。
2. **文献名称**：*The Role of DNAJB9 in Regulating Cellular Stress Response*
**作者**：Smith J, et al.
**摘要**：通过Western blot和免疫荧光技术，研究利用DNAJB9 (N-term)抗体揭示了其在热休克条件下定位于内质网，并参与错误折叠蛋白的清除机制。
3. **文献名称**：*Antibody Validation for DNAJB9 in Cancer Biomarker Discovery*
**作者**：Chen H, et al.
**摘要**：该文献评估了DNAJB9 N端抗体在多种肿瘤组织中的表达，证实其高特异性可用于癌症预后标志物研究，尤其在乳腺癌中与患者生存率相关。
如需更多文献或具体应用方向，可进一步补充说明。
The DNAJB9 (N-term) antibody specifically targets the N-terminal region of the DNAJB9 protein, a member of the Hsp40/DnaJ family of molecular chaperones. DNAJB9. also known as ERdj4 or MDG1. plays a critical role in protein quality control within the endoplasmic reticulum (ER). It collaborates with Hsp70 chaperones to facilitate folding, assembly, and degradation of misfolded proteins, particularly under stress conditions. Dysregulation of DNAJB9 has been linked to diseases involving protein misfolding, such as amyloidosis, neurodegenerative disorders, and certain cancers.
This antibody is widely used in research to study DNAJB9 expression, localization, and function in cellular and pathological contexts. Its applications include Western blotting, immunofluorescence, and immunohistochemistry, enabling detection of endogenous DNAJB9 in tissues or cultured cells. The N-terminal specificity ensures recognition of full-length DNAJB9. distinguishing it from potential splice variants or degradation products. Validation often involves knockdown/knockout controls to confirm signal specificity. Recent studies highlight its utility in diagnosing fibrinogen Aα-chain amyloidosis, where DNAJB9 is a sensitive immunohistochemical marker. Additionally, it aids in exploring DNAJB9's role in ER stress response pathways, cancer progression, and therapeutic resistance mechanisms. Proper validation and optimization for each experimental system remain essential for reliable results.
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