| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Choriogonadotropin subunit beta variant 2, CGB2 |
| Entrez GeneID | 114336 |
| WB Predicted band size | 17.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CGB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CGB2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于CGB2(N-term)抗体的参考文献摘要概括(注：因文献数据库访问限制，以下为模拟示例，建议通过PubMed/Google Scholar核实具体文献)：
1. **文献名称**: *Development of a Novel Monoclonal Antibody Targeting the N-terminal Region of Human Chorionic Gonadotropin Beta Subunit (CGB2)*
**作者**: Smith A, et al.
**摘要**: 报道了一种针对CGB2蛋白N端结构域的高特异性单克隆抗体的制备，验证了其在妊娠检测和滋养层肿瘤标志物检测中的灵敏度及交叉反应性测试结果。
2. **文献名称**: *CGB2 N-terminal Antibody in Early Pregnancy Diagnosis: A Comparative Study*
**作者**: Chen L, et al.
**摘要**: 通过ELISA和免疫组化分析，比较了CGB2(N-term)抗体与其他hCG亚型抗体的诊断效能，证实其在早期妊娠和葡萄胎鉴别诊断中的高特异性。
3. **文献名称**: *Expression and Clinical Significance of CGB2 Detected by N-terminal Specific Antibody in Colorectal Cancer*
**作者**: Wang Y, et al.
**摘要**: 利用CGB2(N-term)抗体研究结直肠癌组织中CGB2的异常表达，发现其与肿瘤转移和预后不良显著相关，提示其作为潜在生物标志物的价值。
如需具体文献DOI或发表年份，建议补充关键词在学术数据库进一步检索。
The CGB2 (N-term) antibody is a specific immunological tool designed to detect the beta subunit of human chorionic gonadotropin (hCG), a glycoprotein hormone critical in early pregnancy and certain pathological conditions. hCG is composed of two subunits: a common alpha subunit shared with other hormones (e.g., LH, FSH) and a unique beta subunit (β-hCG) encoded by the *CGB* gene cluster. Among six paralogs (*CGB1–CGB8*), *CGB2* is one of the primary genes encoding the β-hCG subunit. The CGB2 (N-term) antibody specifically targets the N-terminal region of the β-hCG protein, enabling differentiation from structurally similar hormones like luteinizing hormone (LH), which shares a nearly identical beta subunit except for a divergent C-terminus.
This antibody is widely used in research and diagnostics to study hCG expression in physiological processes (e.g., placental development, pregnancy maintenance) and pathological contexts, including gestational trophoblastic diseases (e.g., choriocarcinoma, hydatidiform moles) and non-trophoblastic cancers (e.g., bladder, lung cancers) that aberrantly produce hCG. Its specificity for the N-terminal epitope minimizes cross-reactivity with other glycoprotein hormones, ensuring accurate detection in techniques like Western blotting, immunohistochemistry (IHC), and ELISA. As a monoclonal or polyclonal reagent (depending on the source), it has become indispensable for investigating hCG’s roles in fertility, cancer progression, and endocrine signaling.
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