首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal SLC4A9(N-term) Antibody

  • 中文名： SLC4A9 (N-term)抗体
  • 别    名： Anion exchange protein 4, AE 4, Anion exchanger 4, Sodium bicarbonate cotransporter 5, Solute carrier family 4 member 9, SLC4A9, AE4, SBC5
货号: IPDX31887
Price： ￥1180
数量：
大包装询价

验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesAnion exchange protein 4, AE 4, Anion exchanger 4, Sodium bicarbonate cotransporter 5, Solute carrier family 4 member 9, SLC4A9, AE4, SBC5
Entrez GeneID83697
WB Predicted band size108.2kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis SLC4A9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-30 amino acids from the N-terminal region of human SLC4A9.
FormulationPurified antibody in PBS with 0.05% sodium azide.

+ +

参考文献

以下是关于SLC4A9(N-term)抗体的3篇参考文献示例(注：文献为虚构，仅作格式示例，实际文献需通过学术数据库验证)：

---

1. **文献名称**: *"Localization and functional characterization of SLC4A9 in the kidney"*

**作者**: Parker MD et al.

**摘要**: 使用针对SLC4A9 N端的特异性抗体，通过免疫组化和Western blot证实其在肾脏远端小管上皮细胞的表达，并揭示其在调节细胞内pH中的作用。

---

2. **文献名称**: *"AE4 (SLC4A9) mediates bicarbonate transport in gastric parietal cells"*

**作者**: Alvarez BV et al.

**摘要**: 通过N端抗体进行免疫荧光和功能实验，证明SLC4A9在胃壁细胞顶膜表达，参与HCO₃⁻分泌，支持胃酸中和机制。

---

3. **文献名称**: *"Interaction of SLC4A9 with carbonic anhydrase II: A structural study"*

**作者**: Lee SK et al.

**摘要**: 利用抗SLC4A9 N端抗体进行共免疫沉淀和共聚焦显微镜分析，揭示其与碳酸酐酶II的物理互作，提出协同调节离子转运的模型。

---

如需真实文献，建议在PubMed或Google Scholar中检索关键词：**SLC4A9 antibody N-terminal**，并筛选应用该抗体的功能或定位研究。

背景信息

The SLC4A9 (solute carrier family 4 member 9) gene encodes AE4. a member of the SLC4 anion exchanger family involved in regulating pH and ion homeostasis. The AE4 protein functions primarily as a chloride/bicarbonate (Cl⁻/HCO3⁻) exchanger, though its exact physiological role remains under investigation. It is expressed in epithelial tissues, notably in the kidney (intercalated cells) and stomach, where it may contribute to acid-base balance and chloride transport. The SLC4A9 (N-term) antibody is specifically designed to target the N-terminal region of the AE4 protein, enabling researchers to study its expression, localization, and interactions. This antibody is commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate AE4's tissue distribution, particularly in renal and gastrointestinal studies. Research has linked SLC4A9 variants to conditions such as hypertension, metabolic alkalosis, and renal tubular acidosis, highlighting its potential role in electrolyte disorders. The N-terminal specificity of the antibody helps distinguish AE4 from other SLC4 family members (e.g., AE1. AE2. AE3) and may aid in detecting full-length protein isoforms. Recent studies also explore AE4's involvement in cancer progression and cellular pH regulation, making this antibody a valuable tool for both basic research and clinical investigations.

客户数据及评论

折叠内容

大包装询价

×