| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MICOS complex subunit MIC25, Coiled-coil-helix cristae morphology protein 1, Coiled-coil-helix-coiled-coil-helix domain-containing protein 6, CHCHD6, CHCM1, MIC25 |
| Entrez GeneID | 84303 |
| WB Predicted band size | 26.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CHCHD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-165 amino acids from the Central region of human CHCHD6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于CHCHD6抗体的3篇参考文献示例(基于研究领域常见方向，内容为示例性概括)：
---
1. **文献名称**: *CHCHD6 regulates mitochondrial apoptosis in cancer cells via interaction with Bcl-2 family proteins*
**作者**: Smith A, et al.
**摘要**: 本研究利用CHCHD6特异性抗体，通过免疫共沉淀和Western blot技术，揭示了CHCHD6通过与Bcl-2家族蛋白相互作用调控线粒体凋亡通路，在乳腺癌细胞中影响化疗敏感性。
2. **文献名称**: *Mitochondrial CHCHD6 stabilizes cristae structure and promotes neuronal survival*
**作者**: Chen L, et al.
**摘要**: 通过免疫荧光和电镜结合CHCHD6抗体，作者发现CHCHD6对维持线粒体嵴结构至关重要，其缺失导致神经元线粒体功能障碍，可能与阿尔茨海默病病理相关。
3. **文献名称**: *CHCHD6 as a novel biomarker in non-small cell lung cancer: Expression profiling and clinical implications*
**作者**: Wang Y, et al.
**摘要**: 研究采用CHCHD6抗体进行组织免疫组化分析，发现CHCHD6在非小细胞肺癌中高表达，且与患者预后不良相关，提示其作为潜在治疗靶点的价值。
---
**注**：以上文献为示例，实际研究中请通过学术数据库(如PubMed、Web of Science)以关键词“CHCHD6 antibody”或“CHCHD6 function”检索最新文献。若需具体文献，建议补充研究场景(如疾病模型、实验方法)以便精准推荐。
CHCHD6 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 6) is a mitochondrial protein belonging to the CHCHD family, which is implicated in regulating mitochondrial structure, dynamics, and function. It localizes to the mitochondrial intermembrane space and interacts with components of the mitochondrial contact site and cristae organizing system (MICOS), playing a role in maintaining cristae integrity and oxidative phosphorylation. CHCHD6 is also linked to cellular stress responses, apoptosis, and metabolic regulation. Dysregulation of CHCHD6 has been associated with neurodegenerative diseases, cancer, and metabolic disorders, highlighting its potential as a therapeutic or diagnostic target.
Antibodies targeting CHCHD6 are essential tools for studying its expression, localization, and interactions. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and co-immunoprecipitation (Co-IP) to investigate its role in mitochondrial physiology and pathology. Validated CHCHD6 antibodies help identify tissue-specific expression patterns, quantify protein levels under disease conditions (e.g., in tumor samples or neuronal tissues), and explore its relationship with apoptosis or metabolic pathways. Specificity is critical, as CHCHD6 shares structural homology with other CHCHD family members (e.g., CHCHD3. CHCHD10). Researchers often confirm antibody specificity using knockout controls or siRNA-mediated knockdown. These antibodies contribute to advancing understanding of mitochondrial dysfunction in diseases like Alzheimer’s, Parkinson’s, and cancer.
×
