| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein 25, Zinc finger protein KOX19, ZNF25, KOX19 |
| Entrez GeneID | 219749 |
| WB Predicted band size | 53.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZNF25 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-81 amino acids from the N-terminal region of human ZNF25. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与ZNF25 (N-terminal)抗体相关的文献概览，基于公开数据库信息推断(注：部分文献可能未直接使用"N-term"标签，但涉及ZNF25蛋白功能研究)：
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1. **文献名称**: *ZNF25 promotes myogenic differentiation by interacting with the chromatin remodeling complex*
**作者**: Lee, H. et al. (2018)
**摘要**: 研究利用ZNF25 (N-term)抗体进行染色质免疫沉淀(ChIP)，发现ZNF25通过结合肌肉分化相关基因启动子，与SWI/SNF复合物协同调控成肌细胞分化。
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2. **文献名称**: *Systematic characterization of zinc finger proteins in human cancer genomes*
**作者**: Zhang, Q. et al. (2020)
**摘要**: 通过Western blot(使用ZNF25 N-term抗体验证蛋白表达)和CRISPR筛选，揭示ZNF25在乳腺癌中作为抑癌基因，其低表达与患者预后不良相关。
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3. **文献名称**: *Proteomic analysis of ZNF25 interactions in transcriptional regulation*
**作者**: Gupta, R. & Schmidt, E. (2016)
**摘要**: 采用N端特异性ZNF25抗体进行免疫共沉淀(Co-IP)，鉴定出ZNF25与RNA聚合酶II亚基及组蛋白修饰酶相互作用，提示其在转录延伸中的潜在作用。
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**备注**：以上文献为模拟示例，实际引用需通过PubMed或Google Scholar以“ZNF25 antibody”或“Zinc Finger Protein 25”为关键词检索具体研究。建议查看抗体供应商(如Santa Cruz、Abcam)的产品说明书，获取已验证应用的原始文献。
The ZNF25 (N-term) antibody is a reagent designed to detect the N-terminal region of zinc finger protein 25 (ZNF25), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein (ZFP) family. ZNF25 is encoded by the *ZNF25* gene in humans and is characterized by tandem C2H2-type zinc finger motifs, which facilitate sequence-specific DNA binding, and an N-terminal KRAB domain known to mediate transcriptional repression through interactions with co-repressors like KAP1. This antibody is typically produced in rabbits or mice using immunogenic peptides corresponding to the N-terminal sequence of ZNF25. ensuring specificity for epitopes within this regulatory region.
ZNF25 is implicated in transcriptional regulation, potentially influencing cellular processes such as differentiation, proliferation, and apoptosis. Its KRAB domain recruits chromatin-modifying complexes, enabling epigenetic silencing of target genes. While the exact biological roles of ZNF25 remain under investigation, studies suggest involvement in developmental pathways and tumor suppression, with dysregulation linked to certain cancers. The ZNF25 (N-term) antibody is widely used in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to study protein expression, subcellular localization, and DNA-binding activity. Researchers rely on this tool to explore ZNF25's interactions, downstream targets, and contributions to gene regulatory networks, particularly in the context of KRAB-ZFP-mediated genome stability and disease mechanisms.
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