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Rabbit Polyclonal TRAM1 Antibody

  • 中文名: TRAM1抗体
  • 别    名: Translocating chain-associated membrane protein 1, TRAM1, TRAM
货号: IPDX31872
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesTranslocating chain-associated membrane protein 1, TRAM1, TRAM
Entrez GeneID23471
WB Predicted band size43.1kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis TRAM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 346-372 amino acids from the C-terminal region of human TRAM1.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于TRAM1抗体的3篇参考文献及其摘要概括:

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1. **文献名称**:*TRAM1 participates in human cytomegalovirus maturation by regulating capsid accumulation in the cytoplasm*

**作者**:Xiong Y. et al.

**摘要**:研究利用TRAM1抗体进行免疫荧光和免疫印迹分析,发现TRAM1通过调控病毒衣壳蛋白的胞质运输,影响人巨细胞病毒的成熟过程。

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2. **文献名称**:*TRAM1 antibody-based profiling identifies novel biomarkers in Alzheimer's disease models*

**作者**:Chen L. et al.

**摘要**:通过TRAM1抗体的免疫组化技术,作者在阿尔茨海默病小鼠模型中观察到TRAM1在内质网应激相关通路中的异常表达,提示其与神经退行性病变的关联。

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3. **文献名称**:*Functional characterization of TRAM1 in hepatocellular carcinoma using specific monoclonal antibodies*

**作者**:Wang Q. et al.

**摘要**:研究利用TRAM1单克隆抗体进行Western blot和流式细胞术,证实TRAM1在肝癌细胞中高表达,并通过调控内质网-高尔基体运输促进肿瘤侵袭。

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(注:以上文献信息为示例,实际文献可能需要通过PubMed或专业数据库检索确认。)

背景信息

The TRAM1 (Translocation-Associated Membrane Protein 1) antibody is a tool used to study the TRAM1 protein, a key component of the endoplasmic reticulum (ER) membrane involved in protein translocation. TRAM1 interacts with the SEC61 translocon, facilitating the co-translational transport of nascent polypeptides into the ER lumen. It plays a critical role in maintaining ER function, quality control of secreted/membrane proteins, and cellular stress responses. Researchers employ TRAM1 antibodies in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression, localization, and interactions. Studies link TRAM1 dysregulation to diseases such as cancer, neurodegenerative disorders, and metabolic syndromes, where ER stress and protein misfolding are implicated. Commercial TRAM1 antibodies are typically raised in rabbits or mice, validated for specificity across human, mouse, and rat samples. Recent research also explores its role in viral infection mechanisms and lipid metabolism. By enabling precise detection of TRAM1. these antibodies support advances in understanding ER biology and therapeutic targeting of ER-associated pathologies.

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