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Rabbit Polyclonal TCERG1 Antibody

  • 中文名: TCERG1抗体
  • 别    名: Transcription elongation regulator 1, TATA box-binding protein-associated factor 2S, Transcription factor CA150, TCERG1, CA150, TAF2S
货号: IPDX31861
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesTranscription elongation regulator 1, TATA box-binding protein-associated factor 2S, Transcription factor CA150, TCERG1, CA150, TAF2S
Entrez GeneID10915
WB Predicted band size123.9kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis TCERG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 991-1020 amino acids from the C-terminal region of human TCERG1.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于TCERG1抗体的参考文献示例:

1. **文献名称**:*TCERG1 regulates alternative splicing by interacting with spliceosomal components*

**作者**:Smith A, et al.

**摘要**:本研究通过免疫共沉淀(Co-IP)和Western blot技术,利用TCERG1特异性抗体,揭示了TCERG1与剪接因子(如SF3B1)的相互作用,表明其在RNA剪接调控中的关键作用。

2. **文献名称**:*Dysregulation of TCERG1 in Huntington’s disease models*

**作者**:Johnson R, et al.

**摘要**:通过免疫组化和小鼠脑组织Western blot分析,作者使用TCERG1抗体发现其表达水平在亨廷顿病模型中显著降低,提示其可能与神经退行性病变相关。

3. **文献名称**:*TCERG1 modulates transcriptional elongation in leukemia cells*

**作者**:Lee H, et al.

**摘要**:结合ChIP-seq和免疫荧光技术(使用TCERG1抗体),研究发现TCERG1通过结合RNA聚合酶Ⅱ调控转录延伸,影响白血病细胞的增殖与分化。

4. **文献名称**:*Development and validation of a monoclonal antibody against human TCERG1*

**作者**:Chen L, et al.

**摘要**:本文报道了一种新型TCERG1单克隆抗体的制备与验证,通过ELISA、免疫印迹和免疫荧光实验证实其高特异性和适用性,为后续功能研究提供工具。

(注:以上文献为示例,非真实存在,仅展示格式与内容框架。)

背景信息

The TCERG1 (Transcription Elongation Regulator 1) antibody is a tool used to detect and study the TCERG1 protein, a conserved eukaryotic factor implicated in transcriptional elongation, RNA splicing, and cellular processes. TCERG1 interacts with RNA polymerase II and spliceosomal components via its WW domains, facilitating the coupling of transcription and pre-mRNA processing. It regulates alternative splicing by modulating the recruitment of splicing factors to nascent transcripts, impacting gene expression diversity. Dysregulation of TCERG1 is linked to cancer, neurodegenerative diseases (e.g., Huntington’s disease), and developmental disorders, highlighting its role in maintaining cellular homeostasis. Researchers use TCERG1 antibodies in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to explore its localization, expression levels, and molecular interactions. Studies also investigate its potential as a therapeutic target, particularly in cancers where its overexpression correlates with tumor progression. The antibody’s specificity is critical for distinguishing TCERG1 isoforms and understanding post-translational modifications that regulate its activity. Commercial TCERG1 antibodies are typically validated for cross-reactivity and batch consistency to ensure experimental reproducibility in both basic and clinical research contexts.

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