| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Mitochondrial sodium/hydrogen exchanger 9B2, Mitochondrial Na(+)/H(+) exchanger NHA2, Na(+)/H(+) exchanger-like domain-containing protein 2, NHE domain-containing protein 2, Sodium/hydrogen exchanger-like domain-containing protein 2, Solute carrier family 9 subfamily B member 2, SLC9B2, NHA2, NHEDC2 |
| Entrez GeneID | 133308 |
| WB Predicted band size | 57.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This NHEDC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 458-486 amino acids from the C-terminal region of human NHEDC2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与NHEDC2(Na+/H+交换器相关蛋白)抗体相关的模拟参考文献示例(注：NHEDC2研究较少，以下内容为假设性示例，实际文献需通过数据库验证)：
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1. **标题**: "Characterization of NHEDC2-Specific Antibodies for Detecting Epithelial Ion Transport"
**作者**: Smith J, et al.
**摘要**: 本研究开发了针对NHEDC2蛋白的多克隆抗体，通过免疫印迹和免疫组化验证其在肾小管上皮细胞中的特异性表达，证实NHEDC2参与细胞pH调节和钠离子转运。
2. **标题**: "NHEDC2 Expression in Gastrointestinal Cancers: A Novel Biomarker Study"
**作者**: Lee H, et al.
**摘要**: 利用抗NHEDC2抗体分析结肠癌组织样本，发现NHEDC2表达水平与肿瘤侵袭性呈正相关，提示其可能作为癌症预后标志物及潜在治疗靶点。
3. **标题**: "Functional Role of NHEDC2 in Neuronal Development Revealed by Antibody Blockade"
**作者**: Garcia R, et al.
**摘要**: 通过特异性抗体抑制NHEDC2功能，发现其缺失导致小鼠神经元突触传递异常，表明NHEDC2在中枢神经系统发育中起关键作用。
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建议通过 **PubMed** 或 **Google Scholar** 以“NHEDC2 antibody”或“SLC9B2”(假设基因名)为关键词检索真实文献。如需进一步协助定位具体论文，可提供更多背景信息。
The NHEDC2 antibody is designed to target the sodium/hydrogen exchanger domain-containing protein 2 (NHEDC2), a transmembrane protein implicated in regulating intracellular pH and ion homeostasis. NHEDC2 belongs to the solute carrier (SLC) family, which facilitates the exchange of sodium (Na⁺) and hydrogen (H⁺) ions across cellular membranes. This protein is primarily expressed in epithelial tissues, including the kidney, gastrointestinal tract, and reproductive organs, where it contributes to acid-base balance, nutrient absorption, and cellular signaling. Dysregulation of NHEDC2 has been linked to pathologies such as hypertension, metabolic acidosis, and certain cancers, highlighting its physiological relevance.
Antibodies against NHEDC2 are essential tools for studying its expression, localization, and function in both normal and disease states. Developed using immunogenic peptide sequences or recombinant protein fragments, these antibodies are validated for applications like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Researchers utilize NHEDC2-specific antibodies to explore its role in ion transport mechanisms, tissue-specific physiology, and potential therapeutic targeting. Recent studies also investigate NHEDC2's interaction with signaling pathways involved in cell proliferation and apoptosis, underscoring its broader impact beyond ion exchange. Robust validation, including knockout controls and tissue-specific expression profiling, ensures antibody specificity, enabling precise detection in complex biological systems.
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