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Rabbit Polyclonal ZNF613 Antibody

  • 中文名: ZNF613抗体
  • 别    名: Zinc finger protein 613, ZNF613
货号: IPDX31857
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesZinc finger protein 613, ZNF613
Entrez GeneID79898
WB Predicted band size70.1kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis ZNF613 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 512-539 amino acids from the C-terminal region of human ZNF613.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于ZNF613抗体的虚构参考文献示例(请注意,以下内容为模拟生成,实际文献需通过学术数据库查询):

1. **文献名称**: *ZNF613 Antibody Characterization and Its Role in Breast Cancer Progression*

**作者**: Smith A, et al.

**摘要**: 本研究开发了一种特异性ZNF613多克隆抗体,并通过Western blot和免疫组化验证其在乳腺癌细胞系中的表达。结果显示,ZNF613在肿瘤组织中表达下调,提示其可能作为抑癌基因参与乳腺癌发展。

2. **文献名称**: *ZNF613 Interaction with Chromatin Remodeling Complexes Revealed by ChIP-seq*

**作者**: Johnson B, et al.

**摘要**: 利用ZNF613抗体进行染色质免疫沉淀测序(ChIP-seq),发现ZNF613广泛结合基因启动子区域,与HDAC复合物相互作用,调控靶基因的表观遗传沉默。

3. **文献名称**: *Developmental Expression Profiling of ZNF613 in Mouse Brain*

**作者**: Lee C, et al.

**摘要**: 通过ZNF613抗体的免疫荧光分析,揭示了该蛋白在小鼠胚胎神经发育中的动态表达模式,提示其在神经元分化和突触形成中的潜在作用。

4. **文献名称**: *ZNF613 Antibody Application in Protein-Protein Interaction Studies*

**作者**: Zhang Y, et al.

**摘要**: 本研究使用ZNF613抗体进行免疫共沉淀(Co-IP),发现其与细胞周期调控蛋白Cyclin D1存在直接结合,为ZNF613参与细胞周期阻滞的机制提供了证据。

**建议**:实际文献需通过PubMed、Google Scholar或Web of Science检索关键词“ZNF613 antibody”或“ZNF613 function”。若研究较少,可扩展至锌指蛋白家族(如ZNF614、ZNF611)相关抗体文献。

背景信息

The ZNF613 antibody is a research tool designed to detect and study the zinc finger protein 613 (ZNF613), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein family. ZNF613 is part of the largest subgroup of transcription factors in humans, characterized by C2H2-type zinc finger motifs that facilitate sequence-specific DNA binding. These proteins are implicated in transcriptional regulation, chromatin remodeling, and cellular processes such as differentiation, apoptosis, and carcinogenesis. ZNF613. located on chromosome 19p13.2. is thought to function as a transcriptional repressor, potentially interacting with chromatin-modifying complexes via its KRAB domain. However, its precise biological roles and target genes remain poorly characterized compared to other zinc finger proteins.

The ZNF613 antibody is typically developed using immunogens derived from specific epitopes of the human ZNF613 protein. It is widely utilized in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate ZNF613 expression patterns across tissues and cell lines. Studies have explored its potential involvement in diseases, including cancers and neurological disorders, though conclusive evidence is limited. Commercial antibodies often undergo validation for specificity using knockout cell lines or siRNA-mediated knockdown. Research involving ZNF613 antibodies aims to clarify its regulatory mechanisms, interaction partners, and pathological relevance, contributing to broader insights into zinc finger protein biology and their roles in human health. Despite progress, functional ambiguity underscores the need for further investigation.

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