| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | PHD finger protein 20-like protein 1, PHF20L1 |
| Entrez GeneID | 51105 |
| WB Predicted band size | 115.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This PHF20L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 912-940 amino acids from the C-terminal region of human PHF20L1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PHF20L1抗体的3篇参考文献示例(内容基于假设性研究，仅供参考)：
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1. **文献名称**：*PHF20L1 regulates histone modification and DNA damage repair through its interaction with 53BP1*
**作者**：Wang, Y., et al.
**摘要**：本研究通过PHF20L1抗体进行免疫共沉淀(Co-IP)和染色质免疫沉淀测序(ChIP-seq)，揭示了PHF20L1通过结合组蛋白H4K20me2标记并与DNA损伤蛋白53BP1相互作用，调控DNA损伤修复通路的功能。
2. **文献名称**：*High expression of PHF20L1 correlates with poor prognosis in colorectal cancer*
**作者**：Li, X., et al.
**摘要**：利用PHF20L1抗体进行免疫组织化学(IHC)分析，发现PHF20L1在结直肠癌组织中显著高表达，且与肿瘤转移和患者生存率降低相关，提示其可能作为潜在的癌症生物标志物。
3. **文献名称**：*PHF20L1 is essential for neural stem cell maintenance and neurogenesis*
**作者**：Chen, J., et al.
**摘要**：通过Western blot和免疫荧光技术(使用PHF20L1特异性抗体)，研究发现PHF20L1在小鼠神经干细胞中高表达，敲除后导致干细胞自我更新能力受损，证实其对神经发育的关键作用。
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**说明**：以上文献为示例，实际研究中需通过PubMed、Google Scholar等平台以关键词“PHF20L1 antibody”或“PHF20L1 function”检索真实发表的论文。若需具体文献，建议结合数据库进一步查询。
The PHF20L1 (PHD Finger Protein 20-Like 1) antibody is a tool used to study the PHF20L1 protein, a member of the PHD (plant homeodomain) zinc finger protein family. PHF20L1 contains a conserved Tudor domain and PHD fingers, structural motifs often involved in chromatin remodeling, epigenetic regulation, and protein-protein interactions. While its exact biological functions remain under investigation, PHF20L1 is hypothesized to play roles in transcriptional regulation, DNA damage response, and cellular differentiation. Studies suggest it may interact with histone modifications or other epigenetic modifiers, potentially influencing gene expression patterns.
Research on PHF20L1 has linked it to cancer biology, with altered expression observed in certain tumors, though its role as an oncogene or tumor suppressor remains unclear. Antibodies targeting PHF20L1 enable detection of its expression levels, subcellular localization (primarily nuclear), and post-translational modifications. These antibodies are critical for techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation, aiding in mechanistic studies of PHF20L1's involvement in disease pathways. Commercial PHF20L1 antibodies vary in clonality (monoclonal/polyclonal) and host species, requiring validation for specificity due to potential cross-reactivity with homologous proteins like PHF20. Ongoing research aims to clarify its molecular interactions and therapeutic relevance.
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