| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial, Phosphatidylglycerophosphate synthase 1, PGP synthase 1, PGS1 |
| Entrez GeneID | 9489 |
| WB Predicted band size | 62.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This PGS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 272-299 amino acids from the Central region of human PGS1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3条关于PGS1抗体的假设性参考文献示例，供参考：
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1. **文献名称**：*"Development of a Polyclonal Antibody Against Yeast Phosphatidylglycerophosphate Synthase 1 (Pgs1p) and Its Application in Mitochondrial Lipid Studies"*
**作者**：Smith J, et al.
**摘要**：本研究报道了一种针对酵母PGS1酶(参与线粒体磷脂生物合成的关键酶)的多克隆抗体的开发。通过免疫印迹和免疫荧光验证了抗体的特异性，并用于探究PGS1缺失对线粒体膜磷脂组成的影响，揭示了其在维持线粒体功能中的作用。
2. **文献名称**：*"Antibody-Based Detection of PGS1 in Mammalian Tissues: Implications for Cardiolipin Biosynthesis"*
**作者**：Lee S, et al.
**摘要**：该研究利用新开发的单克隆抗体，通过免疫组化技术检测了PGS1在小鼠心脏、肝脏等组织中的表达分布，证实了PGS1在心肌磷脂(Cardiolipin)合成中的关键作用，并探讨其与线粒体功能障碍疾病的潜在关联。
3. **文献名称**：*"Targeting PGS1 with a Neutralizing Antibody Suppresses Tumor Growth in Prostate Cancer Models"*
**作者**：Chen X, et al.
**摘要**：研究发现PGS1在前列腺癌细胞中高表达，并通过特异性抗体阻断其活性，显著抑制肿瘤细胞增殖。研究揭示了PGS1作为癌症治疗靶点的潜力，并提供了抗体介导的抑制策略。
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**备注**：以上文献为假设性示例，实际研究中可能需要根据具体数据库(如PubMed、Web of Science)检索真实文献。若需进一步协助查找真实文献，请提供更多背景信息。
The PGS1 antibody targets phosphatidylglycerophosphate synthase 1 (PGS1), a key mitochondrial enzyme involved in cardiolipin biosynthesis. Cardiolipin, a phospholipid predominantly found in mitochondrial inner membranes, is essential for maintaining membrane integrity, electron transport chain function, and apoptosis regulation. PGS1 catalyzes the conversion of phosphatidylglycerol to cardiolipin, making it critical for mitochondrial bioenergetics and dynamics. Dysregulation of PGS1 is linked to mitochondrial disorders, metabolic syndromes, and neurodegenerative diseases like Parkinson’s.
Antibodies against PGS1 are widely used in research to study mitochondrial dysfunction, cellular stress responses, and disease mechanisms. They enable detection of PGS1 expression levels via Western blotting, immunofluorescence, and immunohistochemistry, aiding in the identification of tissue-specific or pathological changes in cardiolipin metabolism. Studies utilizing PGS1 antibodies have provided insights into conditions such as cancer (altered cardiolipin in tumorigenesis), heart failure (mitochondrial membrane destabilization), and Barth syndrome (genetic cardiolipin deficiency). These tools are vital for validating gene-editing models (e.g., CRISPR knockouts) and screening therapeutic compounds targeting mitochondrial pathways. Commercial PGS1 antibodies are typically raised in rabbits or mice, validated for specificity in human, mouse, or rat samples.
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