| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Beta-1-syntrophin, 59 kDa dystrophin-associated protein A1 basic component 1, DAPA1B, BSYN2, Syntrophin-2, Tax interaction protein 43, TIP-43, SNTB1, SNT2B1 |
| Entrez GeneID | 6641 |
| WB Predicted band size | 58.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This SNTB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-271 amino acids from the Central region of human SNTB1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SNTB1抗体的3篇参考文献及其摘要内容的简要概括：
1. **文献名称**：*SNTB1 regulates cell proliferation and apoptosis in colorectal cancer by modulating the PI3K/Akt pathway*
**作者**：Li, X., Zhang, Y., & Wang, H.
**摘要**：该研究利用SNTB1抗体通过免疫组化和Western blot技术，发现SNTB1在结直肠癌组织中高表达，并通过调控PI3K/Akt信号通路促进肿瘤细胞增殖并抑制凋亡。
2. **文献名称**：*Syntrophin β1 interacts with the dystrophin glycoprotein complex and regulates neuronal differentiation*
**作者**：Smith, J.R., et al.
**摘要**：作者使用SNTB1抗体进行免疫共沉淀和免疫荧光实验，证明SNTB1与肌营养不良蛋白糖蛋白复合物(DGC)相互作用，影响神经元的形态发生和分化过程。
3. **文献名称**：*Development and validation of a monoclonal antibody specific for human SNTB1 in diagnostic applications*
**作者**：Chen, L., et al.
**摘要**：该文献报道了一种高特异性的SNTB1单克隆抗体的开发与验证，通过ELISA、流式细胞术和免疫组织化学证实其在多种组织样本中的灵敏度和特异性，为SNTB1相关疾病的诊断提供工具。
(注：上述文献为示例性内容，实际文献需通过学术数据库检索确认。)
The SNTB1 antibody targets syntrophin beta-1 (SNTB1), a scaffolding protein belonging to the syntrophin family, which plays a critical role in organizing membrane-associated protein complexes. SNTB1 contains multiple protein interaction domains, including PDZ and pleckstrin homology (PH) domains, enabling it to link signaling molecules, ion channels, or receptors to the cytoskeleton. It is widely expressed in tissues, particularly in neuronal and muscle cells, where it interacts with dystrophin-associated proteins to maintain structural integrity and regulate signal transduction pathways. Dysregulation of SNTB1 has been implicated in neurological disorders, muscular dystrophies, and cancer, where altered expression may influence cell adhesion, migration, or proliferation.
SNTB1 antibodies are essential tools for studying its expression, localization, and interactions in disease models. Researchers employ these antibodies in techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation to explore SNTB1’s functional roles. For instance, studies have linked SNTB1 to cancer progression through its involvement in pathways like PI3K/AKT and its potential as a biomarker. Additionally, SNTB1 antibodies aid in elucidating mechanisms underlying neurodevelopmental defects or muscle degeneration, offering insights for therapeutic targeting. Their specificity and reliability are critical for validating experimental findings across basic and translational research contexts.
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