| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger and SCAN domain-containing protein 31, Zinc finger protein 323, ZSCAN31, ZNF310P, ZNF323 |
| Entrez GeneID | 64288 |
| WB Predicted band size | 47.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZNF323 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 190-217 amino acids from the Central region of human ZNF323. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZNF323抗体的虚构示例参考文献(仅供参考，实际文献需通过学术数据库查询)：
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1. **文献名称**: *ZNF323 Antibody Reveals Its Role in Neurodegenerative Disease Modulation*
**作者**: Smith J, et al. (2015)
**摘要**: 本研究利用ZNF323特异性抗体，发现其在亨廷顿病患者脑组织中表达下调，可能通过调控氧化应激相关通路影响疾病进展，为神经保护机制提供新方向。
2. **文献名称**: *Clinical Significance of ZNF323 in Non-Small Cell Lung Cancer*
**作者**: Zhang L, et al. (2018)
**摘要**: 通过ZNF323抗体免疫组化分析肺癌组织，发现低表达与患者预后不良相关，提示ZNF323可能作为抑癌基因通过调控细胞周期抑制肿瘤增殖。
3. **文献名称**: *ZNF323 Autoantibody as a Biomarker in Rheumatoid Arthritis*
**作者**: Wang Y, et al. (2020)
**摘要**: 研究证实类风湿关节炎患者血清中ZNF323自身抗体水平升高，且与IL-6等炎症因子正相关，或成为疾病活动度的潜在血清标志物。
4. **文献名称**: *ZNF323 Antibody-Based Drug Screening in Myeloma Models*
**作者**: Chen R, et al. (2021)
**摘要**: 使用ZNF323抗体建立体外药物筛选平台，发现靶向降解ZNF323蛋白的化合物可增强多发性骨髓瘤细胞对化疗敏感性。
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**备注**：以上内容为模拟示例，实际文献请通过PubMed、Web of Science或Google Scholar等平台，以关键词“ZNF323 antibody”、“ZNF323 function”等检索获取。
The ZNF323 antibody is a research tool designed to detect ZNF323 (zinc finger protein 323), a member of the zinc finger protein family involved in transcriptional regulation. ZNF323. also known as ZFP323. contains characteristic C2H2-type zinc finger motifs at its C-terminal region, enabling DNA or protein interactions. It plays roles in cell differentiation, apoptosis, and immune responses, with studies linking it to neuropsychiatric disorders (e.g., schizophrenia, bipolar disorder) and cancers (e.g., hepatocellular carcinoma, lung cancer). In Alzheimer’s disease models, ZNF323 may regulate amyloid-beta production by interacting with APP and BACE1.
The antibody, typically developed in hosts like rabbits or mice, is used in techniques such as Western blot, immunohistochemistry, and ChIP to study ZNF323’s expression, localization, and interactions. Its N-terminal region, rich in proline and acidic residues, may influence transcriptional activation or repression. Research using this antibody has highlighted ZNF323’s dual roles: as a potential tumor suppressor in certain cancers and a risk factor in autoimmune diseases like lupus. Its study aids in unraveling disease mechanisms and exploring diagnostic or therapeutic targets. Validation via knockout models or siRNA is essential to ensure specificity due to structural similarities among zinc finger proteins.
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