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Rabbit Polyclonal FAM164A Antibody

  • 中文名： FAM164A抗体
  • 别    名： Zinc finger C2HC domain-containing protein 1A, ZC2HC1A, C8orf70, FAM164A
货号: IPDX31824
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesZinc finger C2HC domain-containing protein 1A, ZC2HC1A, C8orf70, FAM164A
Entrez GeneID51101
WB Predicted band size35.1kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis FAM164A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 271-298 amino acids from the C-terminal region of human FAM164A.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇关于FAM164A抗体的虚构参考文献示例(注：实际文献需通过数据库查询，以下内容仅供格式参考)：

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1. **文献名称**：*FAM164A is a ciliary basal body component regulating ciliogenesis in mammalian cells*

**作者**：Smith J, et al.

**摘要**：本研究利用FAM164A特异性抗体进行免疫荧光和免疫印迹实验，发现FAM164A定位于纤毛基体，并证明其通过调控微管稳定性参与纤毛形成。基因敲除实验表明FAM164A缺失导致纤毛结构异常。

2. **文献名称**：*Antibody-based profiling of FAM164A in colorectal cancer progression*

**作者**：Zhang L, et al.

**摘要**：通过FAM164A多克隆抗体对结直肠癌组织进行免疫组化分析，发现FAM164A在转移性肿瘤中高表达，并与患者预后不良相关。体外实验证实其通过Wnt/β-catenin通路促进癌细胞侵袭。

3. **文献名称**：*Characterization of a novel monoclonal antibody against human FAM164A*

**作者**：Jones R, et al.

**摘要**：报道了一种针对人源FAM164A蛋白的单克隆抗体的开发与验证。该抗体在Western blot及免疫沉淀中表现高特异性，成功应用于检测多种细胞系中FAM164A的亚细胞定位及表达差异。

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**提示**：实际文献建议通过PubMed、Google Scholar等平台以“FAM164A antibody”或“FAM164A function”为关键词检索，并筛选涉及抗体应用的实验研究。

背景信息

The FAM164A antibody is a tool used to detect the FAM164A protein, encoded by the FAM164A gene, which is a relatively understudied member of the FAM164 family. FAM164A is implicated in cellular processes such as ciliogenesis, centrosome regulation, and cell cycle progression. The protein contains conserved coiled-coil domains, suggesting roles in protein-protein interactions or structural scaffolding. Research has linked FAM164A to primary cilia formation, neuronal development, and potential involvement in cancers, including breast and prostate cancer, where its dysregulation may influence tumor progression. The antibody is typically produced in hosts like rabbits or mice, using immunogenic peptides or recombinant protein fragments. It is validated for applications such as Western blotting, immunofluorescence, and immunohistochemistry to visualize FAM164A's subcellular localization (e.g., centrosomes or ciliary bases) and expression patterns in tissues or disease models. Commercial FAM164A antibodies often undergo specificity checks via knockout cell validation. Ongoing studies aim to clarify its molecular mechanisms, interactome, and therapeutic relevance in ciliopathies or malignancies. However, limited literature and potential cross-reactivity with homologous proteins (e.g., FAM164B) necessitate careful experimental controls.

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