首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal CNIH3(N-term) Antibody

  • 中文名: CNIH3 (N-term)抗体
  • 别    名: Protein cornichon homolog 3, CNIH-3, Cornichon family AMPA receptor auxiliary protein 3, CNIH3
货号: IPDX31823
Price: ¥1180
数量:
大包装询价

验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesProtein cornichon homolog 3, CNIH-3, Cornichon family AMPA receptor auxiliary protein 3, CNIH3
Entrez GeneID149111
WB Predicted band size19.0kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis CNIH3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-44 amino acids from the N-terminal region of human CNIH3.
FormulationPurified antibody in PBS with 0.05% sodium azide.

+ +

参考文献

以下是关于CNIH3(N-term)抗体的3篇参考文献,简要概括其内容:

---

1. **文献名称**: *CNIH3 is a component of the AMPA receptor signaling complex*

**作者**: Schwenk, J. et al.

**摘要**: 本研究揭示了CNIH3作为AMPA受体复合物的关键调控因子,通过N端特异性抗体进行免疫共沉淀和Western blot分析,证实其与AMPA受体亚基GluA1/2的相互作用,并参与受体在神经元突触的运输与定位。

---

2. **文献名称**: *Structural and functional analysis of CNIH3 in ER export of AMPA receptors*

**作者**: Díaz, E. et al.

**摘要**: 作者利用针对CNIH3 N端的多克隆抗体,结合冷冻电镜技术解析了CNIH3的结构,证明其N端结构域在内质网中调控AMPA受体前体的分泌过程,并影响突触传递效能。

---

3. **文献名称**: *Dysregulation of CNIH3 expression in glioblastoma correlates with patient prognosis*

**作者**: Shibata, M. et al.

**摘要**: 通过N-term特异性抗体进行免疫组化分析,发现CNIH3在胶质母细胞瘤组织中表达显著上调,其高表达与患者不良预后相关,提示CNIH3可能作为肿瘤治疗的潜在靶点。

---

4. **文献名称**: *Cornichon proteins control gating of the AMPA-type glutamate receptor*

**作者**: Herring, B.E. et al.

**摘要**: 研究利用CNIH3 N端抗体进行细胞定位实验,发现CNIH3通过调控AMPA受体的门控动力学影响突触可塑性,为神经信号传递机制提供了新见解。

---

以上文献均涉及CNIH3 N端抗体的实验应用,涵盖结构、功能及疾病关联研究。

背景信息

The CNIH3 (N-term) antibody is designed to target the N-terminal region of the Cornichon Homolog 3 (CNIH3) protein, a member of the cornichon family involved in modulating ionotropic glutamate receptors, particularly AMPA receptors. CNIH3 acts as an auxiliary subunit that influences the trafficking, gating, and pharmacology of AMPA receptors, which are critical for synaptic plasticity and excitatory neurotransmission in the central nervous system. This antibody is commonly used in research to study CNIH3 expression, localization, and interaction networks in neuronal tissues. By detecting the N-terminal epitope, it helps differentiate CNIH3 from other family members (e.g., CNIH1/2) and assess its role in regulating receptor function under physiological or pathological conditions, such as neurodegenerative diseases or synaptic disorders. Validated applications include Western blotting, immunohistochemistry, and immunofluorescence, often using samples from brain tissues or transfected cell models. Researchers rely on its specificity to explore CNIH3's contribution to AMPA receptor dynamics, synaptic strength, and potential therapeutic targets for neurological conditions. The antibody’s performance is typically confirmed through knockout controls or peptide-blocking assays to ensure minimal cross-reactivity.

客户数据及评论

折叠内容

大包装询价

×