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Rabbit Polyclonal CHERP Antibody

  • 中文名: CHERP抗体
  • 别    名: Calcium homeostasis endoplasmic reticulum protein, ERPROT 213-21, SR-related CTD-associated factor 6, CHERP (<a href="http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=16930" target="_blank">HGNC:16930</a>)
货号: IPDX31822
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCalcium homeostasis endoplasmic reticulum protein, ERPROT 213-21, SR-related CTD-associated factor 6, CHERP (HGNC:16930)
Entrez GeneID10523
WB Predicted band size103.7kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis CHERP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 877-903 amino acids from the C-terminal region of human CHERP.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于CHERP抗体的3篇代表性文献的示例(文献信息为示例性质,具体文献需根据实际检索结果调整):

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1. **文献名称**: "CHERP regulates calcium homeostasis by interacting with SERCA2 in human cells"

**作者**: Yamamoto K, et al.

**摘要**: 本研究利用CHERP特异性抗体,通过免疫共沉淀和免疫荧光技术,揭示了CHERP蛋白与内质网钙泵SERCA2的相互作用,证实其在维持细胞内钙稳态中的关键作用。

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2. **文献名称**: "A novel role of CHERP in DNA damage response via modulating alternative splicing"

**作者**: Li J, et al.

**摘要**: 通过CHERP抗体的Western blot和免疫组化分析,作者发现CHERP通过调控RNA剪接机制参与DNA损伤修复通路,为癌症治疗提供了潜在靶点。

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3. **文献名称**: "Commercial antibody validation for CHERP: Specificity and application in neuronal studies"

**作者**: Abcam Technical Team

**摘要**: 该技术报告详细验证了CHERP抗体(货号abXXXXX)在人类和小鼠脑组织中的特异性,支持其在免疫印迹、免疫细胞化学中的可靠性,并提供了神经元中CHERP表达的定位数据。

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如需具体文献,建议通过PubMed或Google Scholar以关键词“CHERP antibody”、“CHERP protein function”进一步检索。

背景信息

The CHERP (Calcium Homeostasis Endoplasmic Reticulum Protein) antibody is a research tool developed to study the CHERP protein, which plays dual roles in cellular processes. Initially identified as a regulator of calcium signaling, CHERP interacts with the inositol 1.4.5-trisphosphate receptor (IP3R) on the endoplasmic reticulum (ER), influencing intracellular calcium release and homeostasis. Subsequent studies revealed its involvement in RNA splicing, where it associates with spliceosomal components and serine/arginine-rich (SR) proteins, linking calcium signaling to pre-mRNA processing. This dual functionality positions CHERP as a critical molecule bridging calcium dynamics and gene expression regulation. Researchers use CHERP antibodies primarily in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression, localization, and interactions in various tissues and disease models. Dysregulation of CHERP has been implicated in cancers, neurological disorders, and cardiovascular diseases, making its antibody a valuable reagent for exploring molecular mechanisms in these contexts. Commercial CHERP antibodies are typically raised in rabbits or mice against specific epitopes, with validation in human, mouse, and rat samples. Ongoing research continues to elucidate CHERP's role in cellular stress responses and its potential as a therapeutic target.

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