| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | COMM domain-containing protein 9, COMMD9 |
| Entrez GeneID | 29099 |
| WB Predicted band size | 21.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This COMMD9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-176 amino acids from the C-terminal region of human COMMD9. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是假设的关于COMMD9抗体的参考文献示例(请注意，这些文献为虚构，仅供格式参考)：
1. **"COMMD9 as a Novel Biomarker in Hepatocellular Carcinoma: Expression Analysis Using a Specific Polyclonal Antibody"**
*Authors: Smith A, et al. (2021)*
**摘要**：本研究通过开发兔源多克隆抗体，检测COMMD9在肝细胞癌(HCC)组织中的表达，发现其高表达与患者预后不良相关，提示COMMD9可能作为HCC的潜在治疗靶点。
2. **"Interaction of COMMD9 with CCDC22/CCDC93 Complex in Endosomal Trafficking"**
*Authors: Zhang L, et al. (2020)*
**摘要**：利用抗COMMD9单克隆抗体进行免疫共沉淀(Co-IP)实验，揭示COMMD9与CCDC22/CCDC93复合物结合，调控细胞内吞运输过程，影响EGFR信号通路。
3. **"COMMD9 Suppresses NF-κB Activation via Antibody-Based Functional Studies"**
*Authors: Brown K, et al. (2019)*
**摘要**：通过Western blot和免疫荧光技术，验证抗COMMD9抗体在炎症模型中的作用，证实COMMD9通过抑制NF-κB活性减少促炎因子释放。
4. **"Clinical Significance of COMMD9 in Gastric Cancer: Immunohistochemical Analysis"**
*Authors: Lee J, et al. (2022)*
**摘要**：采用抗COMMD9抗体对胃癌组织进行免疫组化(IHC)检测，发现低表达COMMD9与淋巴结转移和TNM分期相关，提示其作为肿瘤抑制因子的潜力。
**备注**：实际文献需通过PubMed或Web of Science等数据库检索，建议结合具体研究需求筛选。
The COMMD9 antibody is a research tool targeting the COMM domain-containing protein 9. a member of the conserved COMMD family involved in diverse cellular processes. COMMD proteins, including COMMD9. regulate copper metabolism, NF-κB signaling, and endosomal trafficking. COMMD9 specifically interacts with the Cullin-RING E3 ubiquitin ligase complex, modulating substrate recognition and ubiquitination processes. It is implicated in cellular homeostasis, cancer progression, and neurological disorders, though its precise mechanisms remain under investigation.
COMMD9 antibodies are typically developed in hosts like rabbits or mice, using immunogens derived from human COMMD9 protein regions. These antibodies are validated for applications such as Western blotting, immunofluorescence, and immunohistochemistry to detect COMMD9 expression in tissues or cell lines. Researchers utilize them to explore COMMD9's role in diseases, including tumors (e.g., liver or colorectal cancers) where dysregulation is observed, or in copper-related pathologies. Specificity is confirmed via knockout controls or siRNA silencing. Commercial variants may include monoclonal or polyclonal formats, with reactivity across species like human, mouse, and rat. As COMMD9 gains attention for its regulatory functions, its antibody serves as a critical reagent for unraveling its biological significance and therapeutic potential.
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