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Rabbit Polyclonal RTN2(N-term) Antibody

  • 中文名: RTN2 (N-term)抗体
  • 别    名: Reticulon-2, Neuroendocrine-specific protein-like 1, NSP-like protein 1, Neuroendocrine-specific protein-like I, NSP-like protein I, NSPLI, RTN2, NSPL1
货号: IPDX31818
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesReticulon-2, Neuroendocrine-specific protein-like 1, NSP-like protein 1, Neuroendocrine-specific protein-like I, NSP-like protein I, NSPLI, RTN2, NSPL1
Entrez GeneID6253
WB Predicted band size59.3kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis RTN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-138 amino acids from the N-terminal region of human RTN2.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于RTN2 (N-term)抗体的假设性参考文献示例(请注意,这些文献为模拟内容,实际引用时需核实真实来源):

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1. **文献名称**: *Reticulon 2-Mediated Axon Regeneration in the Central Nervous System*

**作者**: Smith A, et al.

**摘要**: 本研究利用针对RTN2 N端的特异性抗体,通过免疫组化和Western blot分析,揭示了RTN2在成年小鼠中枢神经轴突再生中的作用。结果显示,RTN2通过调节内质网膜形态促进神经元损伤修复。

2. **文献名称**: *RTN2 Interaction with Bcl-2 Family Proteins in Apoptosis Regulation*

**作者**: Chen L, et al.

**摘要**: 通过RTN2 (N-term)抗体的免疫共沉淀和共聚焦显微技术,研究发现RTN2的N端结构域与Bcl-2家族蛋白相互作用,调控线粒体途径的细胞凋亡,为神经退行性疾病机制提供了新见解。

3. **文献名称**: *Role of RTN2 in Amyloid-β Production in Alzheimer’s Disease Models*

**作者**: Johnson R, et al.

**摘要**: 使用N端特异性RTN2抗体进行组织染色和蛋白质印迹,证实RTN2通过影响γ-分泌酶活性参与β-淀粉样蛋白生成,提示其作为阿尔茨海默病潜在治疗靶点。

4. **文献名称**: *Development and Validation of an Anti-RTN2 N-Terminal Antibody for Neurodevelopmental Studies*

**作者**: Kim S, et al.

**摘要**: 描述了RTN2 N端抗体的制备与验证(包括表位定位和特异性测试),并应用于胚胎小鼠脑组织研究,证明RTN2在神经突触形成中的时空表达模式。

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**备注**:上述文献为示例性质,实际研究中请通过学术数据库(如PubMed、Web of Science)检索真实文献。若需具体文献支持,建议补充关键词或研究背景进一步筛选。

背景信息

The RTN2 (N-term) antibody is designed to target the N-terminal region of reticulon 2 (RTN2), a member of the reticulon protein family (RTN1-4). Reticulons are endoplasmic reticulum (ER)-associated proteins characterized by a conserved C-terminal reticulon homology domain (RHD) and variable N-terminal domains. RTN2 is ubiquitously expressed but enriched in the central nervous system, where it localizes to the ER and participates in ER membrane shaping, vesicle trafficking, and neuronal maintenance. Alternative splicing generates multiple RTN2 isoforms (e.g., RTN2-A, RTN2-B), differing in their N-terminal sequences. The RTN2 (N-term) antibody specifically recognizes epitopes within the variable N-terminal region, enabling isoform-selective detection in applications like Western blotting, immunofluorescence, or immunohistochemistry. Research implicates RTN2 in neurodegenerative diseases, such as Alzheimer’s disease, where its interaction with β-secretase (BACE1) may influence amyloid-beta production. This antibody serves as a critical tool for investigating RTN2’s isoform-specific functions, subcellular localization, and pathological roles in neurological disorders. Validation typically includes testing reactivity against recombinant RTN2 fragments and confirming absence of cross-reactivity with other reticulon family members.

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