| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Guanine nucleotide-binding protein-like 1, GTP-binding protein HSR1, GNL1, HSR1 |
| Entrez GeneID | 2794 |
| WB Predicted band size | 68.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This GNL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 240-266 amino acids from the Central region of human GNL1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于GNL1抗体的3篇参考文献示例(注：文献为假设性描述，实际文献需通过学术数据库检索确认)：
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1. **文献名称**：*GNL1 regulates ribosomal RNA processing and cell proliferation via its interaction with nucleolar proteins*
**作者**：Zhang Y, et al.
**摘要**：本研究探讨了GNL1在核糖体RNA生物合成中的作用，通过使用特异性GNL1抗体进行免疫沉淀和Western blot分析，发现GNL1与核仁蛋白NPM1相互作用，调控细胞周期进程和癌细胞增殖。
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2. **文献名称**：*Development of a monoclonal antibody against human GNL1 for diagnostic applications in hepatocellular carcinoma*
**作者**：Wang L, et al.
**摘要**：研究团队开发了一种高特异性GNL1单克隆抗体，通过免疫组化验证其在肝癌组织中的高表达，表明GNL1可能作为肝癌的潜在生物标志物，抗体可用于临床样本检测。
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3. **文献名称**：*GNL1 knockdown impairs mitochondrial function via antibody-mediated inhibition in glioblastoma cells*
**作者**：Chen H, et al.
**摘要**：利用抗GNL1抗体阻断其功能后，胶质母细胞瘤细胞的线粒体代谢显著受损，提示GNL1在肿瘤能量代谢中的关键作用，为靶向治疗提供了实验依据。
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如需具体文献，建议通过PubMed、Google Scholar等平台检索关键词“GNL1 antibody”或“GNL1 function”，并筛选近年发表的实验研究类论文。
**Background of GNL1 Antibody**
GNL1 (G Protein Nucleolar 1), also known as Ngp-1 or Nucleostemin, is a GTP-binding protein predominantly localized in the nucleolus. It belongs to the MMR_HSR1 GTPase family and plays critical roles in ribosome biogenesis, cell cycle regulation, and stem cell maintenance. GNL1 is highly expressed in proliferating cells, including cancer stem cells and embryonic stem cells, where it supports ribosomal RNA (rRNA) processing and stabilizes the nucleolar structure during rapid cell division.
Antibodies targeting GNL1 are essential tools for studying its expression, localization, and function in cellular processes. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate GNL1 dynamics during the cell cycle, differentiation, or stress responses. Research has linked aberrant GNL1 expression to tumorigenesis, as its overexpression is observed in various cancers, including glioblastoma, hepatocellular carcinoma, and breast cancer, where it correlates with poor prognosis and therapeutic resistance.
GNL1 antibodies also aid in exploring its interaction partners, such as p53 and other nucleolar proteins, shedding light on mechanisms underlying cell senescence and apoptosis. Additionally, they are utilized in developmental biology to study stem cell pluripotency and tissue regeneration. Due to its dual role in ribosome assembly and cell proliferation, GNL1 is emerging as a potential biomarker and therapeutic target, driving demand for high-specificity antibodies in both basic and translational research.
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