| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | F-box/WD repeat-containing protein 9, F-box and WD-40 domain-containing protein 9, FBXW9, FBW9 |
| Entrez GeneID | 84261 |
| WB Predicted band size | 50.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This FBXW9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 5-31 amino acids from the N-terminal region of human FBXW9. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于FBXW9(N-term)抗体的参考文献示例(注：以下文献为模拟虚构，实际文献需通过学术数据库检索确认)：
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1. **文献名称**：*Characterization of FBXW9 (N-term) Antibody in Ubiquitination Pathways*
**作者**：Smith A, et al.
**摘要**：本研究验证了FBXW9(N-term)抗体的特异性，并通过免疫沉淀和Western blot分析发现FBXW9与Cullin1结合，参与调控细胞周期蛋白的泛素化降解，提示其在细胞周期调控中的作用。
2. **文献名称**：*FBXW9 Expression in Neurodegenerative Disease Models*
**作者**：Lee H, et al.
**摘要**：利用FBXW9(N-term)抗体检测小鼠脑组织，发现FBXW9在阿尔茨海默病模型中表达上调，可能通过促进错误折叠蛋白的降解影响疾病进程。
3. **文献名称**：*Development and Application of a Novel FBXW9 N-terminal Antibody*
**作者**：Zhang Y, et al.
**摘要**：报道了一种高特异性FBXW9(N-term)抗体的制备方法，证实其适用于免疫荧光和流式细胞术，并揭示FBXW9在肝癌细胞中异常低表达，可能与肿瘤发生相关。
4. **文献名称**：*FBXW9 Interaction with Viral Proteins Revealed by Immunoprecipitation*
**作者**：Garcia R, et al.
**摘要**：通过FBXW9(N-term)抗体进行免疫共沉淀实验，发现FBXW9与某些病毒蛋白相互作用，可能干扰宿主泛素化系统，为病毒感染机制提供新见解。
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**注意**：以上文献为示例，实际研究中请通过PubMed、Web of Science等平台检索真实文献。FBXW9相关研究较少，建议扩大检索范围至F-box蛋白家族或泛素连接酶复合体相关研究。
The FBXW9 (N-term) antibody is designed to detect the N-terminal region of the F-box/WD repeat-containing protein 9 (FBXW9), a member of the F-box protein family. F-box proteins are critical components of the SCF (SKP1-CUL1-F-box) ubiquitin ligase complexes, which mediate substrate recognition and ubiquitination, targeting proteins for proteasomal degradation. FBXW9 contains an F-box domain for binding SKP1 and WD40 repeats for substrate interaction, though its specific biological roles remain less characterized compared to other FBXW members (e.g., FBXW7. a well-known tumor suppressor).
The N-terminal region targeted by this antibody may encompass regulatory or protein-binding motifs essential for FBXW9's function. Researchers utilize this antibody in techniques like Western blotting, immunoprecipitation, or immunofluorescence to study FBXW9 expression, localization, and interactions in cellular contexts. Its application aids in elucidating FBXW9's involvement in processes such as cell cycle regulation, signal transduction, or protein homeostasis.
Validation of the antibody typically includes testing in knockout cell lines or tissues to confirm specificity. As FBXW9's exact substrates and pathways are still under investigation, this reagent serves as a key tool for exploring its contribution to cellular mechanisms and potential disease associations.
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