关键信息
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基因名
STAT5A
- 应用
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别名
STAT5A；STAT5；Signal transducer and activator of transcription 5A
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种属
Human
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表达系统
E. coli
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标签
N-his
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P42229
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表达区间
1-794aa
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氨基酸序列
MAGWIQAQQL QGDALRQMQV LYGQHFPIEV RHYLAQWIES QPWDAIDLDN PQDRAQATQL LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQKTYDR CPLELVRCIR HILYNEQRLV REANNCSSPA GILVDAMSQK HLQINQTFEE LRLVTQDTEN ELKKLQQTQE YFIIQYQESL RIQAQFAQLA QLSPQERLSR ETALQQKQVS LEAWLQREAQ TLQQYRVELA EKHQKTLQLL RKQQTIILDD ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL NVHMNPPQVK ATIISEQQAK SLLKNENTRN ECSGEILNNC CVMEYHQATG TLSAHFRNMS LKRIKRADRR GAESVTEEKF TVLFESQFSV GSNELVFQVK TLSLPVVVIV HGSQDHNATA TVLWDNAFAE PGRVPFAVPD KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNN SSSHLEDYSG LSVSWSQFNR ENLPGWNYTF WQWFDGVMEV LKKHHKPHWN DGAILGFVNK QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSPERNL WNLKPFTTRD FSIRSLADRL GDLSYLIYVF PDRPKDEVFS KYYTPVLAKA VDGYVKPQIK QVVPEFVNAS ADAGGSSATY MDQAPSPAVC PQAPYNMYPQ NPDHVLDQDG EFDLDETMDV ARHVEELLRR PMDSLDSRLS PPAGLFTSAR GSLS
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分子量
92kda
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, 5% Trehalose
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
STAT5A (Signal Transducer and Activator of Transcription 5A) is a crucial transcription factor involved in various cellular processes, including growth, differentiation, and immune responses. As a member of the STAT family, STAT5A plays a significant role in mediating signals from cytokines and growth factors, particularly in hematopoietic and immune cells. Dysregulation of STAT5A has been implicated in several pathologies, including cancer, where it contributes to oncogenesis and tumor progression through aberrant activation. The study of recombinant STAT5A proteins has emerged as a pivotal area of research, providing insights into the structure-function relationships of STAT proteins and their regulatory mechanisms. By producing STAT5A in a recombinant system, researchers can investigate its signaling pathways, identify potential targets for therapeutic intervention, and elucidate its role in both normal physiology and disease states. Furthermore, recombinant STAT5A proteins can serve as valuable tools for developing assays and experimental models aimed at understanding the complexities of the JAK/STAT signaling pathway and its implications in various biological contexts. The ongoing characterization of STAT5A through recombinant technology not only enhances our understanding of its functional roles but also paves the way for innovative therapeutic approaches targeting STAT5A-related pathways in human diseases.
