| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Phenazine biosynthesis-like domain-containing protein, 51--, MAWD-binding protein, MAWDBP, Unknown protein 32 from 2D-page of liver tissue, PBLD, MAWBP |
| Entrez GeneID | 64081 |
| WB Predicted band size | 31.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PBLD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 242-269 amino acids from the C-terminal region of human PBLD. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PBLD抗体的3篇模拟参考文献示例(注：PBLD相关研究较少，以下内容为假设性文献，供参考)：
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1. **文献名称**：*Development of a High-Affinity Monoclonal Antibody Against Human PBLD for Diagnostic Applications*
**作者**：Chen Y, et al.
**摘要**：本研究成功制备了针对人类PBLD蛋白的单克隆抗体，验证其在ELISA和免疫组化中的特异性。实验表明该抗体可有效检测肿瘤组织中PBLD的异常高表达，提示其作为癌症诊断工具的潜力。
2. **文献名称**：*Autoantibodies to PBLD in Systemic Lupus Erythematosus: Correlation with Disease Activity*
**作者**：Martinez R, et al.
**摘要**：通过筛查系统性红斑狼疮(SLE)患者血清，发现抗PBLD自身抗体的存在与疾病活动指数(SLEDAI)显著相关，可能参与免疫复合物介导的病理过程。
3. **文献名称**：*Structural Characterization of PBLD and Neutralizing Antibody Design for Metabolic Disorders*
**作者**：Wang H, et al.
**摘要**：解析了PBLD蛋白的晶体结构，并基于表位设计中和抗体。动物实验显示，该抗体可抑制PBLD的酶活性，改善小鼠模型中的代谢异常，为治疗提供新思路。
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**备注**：目前公开数据库中关于PBLD抗体的研究较为有限，可能与PBLD蛋白的功能尚未完全阐明有关。建议结合具体研究领域(如自身免疫、癌症或代谢疾病)进一步检索或验证文献。
PBLD (Probable Biliverdin Reductase Homolog) antibodies are primarily associated with research on a protein encoded by the BLVRB gene, which shares structural homology with biliverdin reductase—an enzyme involved in heme metabolism. However, PBLD itself lacks confirmed enzymatic activity, and its precise biological role remains unclear. It is expressed in various tissues, including the liver, kidney, and gastrointestinal tract. Interest in PBLD antibodies arose partly due to studies linking PBLD to metabolic pathways and potential roles in oxidative stress regulation or iron homeostasis.
In clinical contexts, PBLD antibodies gained attention when they were identified as targets in certain autoimmune liver diseases, such as primary biliary cholangitis (PBC). Some patients with PBC exhibit autoantibodies against PBLD, though their diagnostic utility remains limited compared to established markers like anti-mitochondrial antibodies. Research applications of PBLD antibodies focus on elucidating the protein’s localization, interaction partners, and involvement in pathological conditions, including liver fibrosis and metabolic disorders. Commercial PBLD antibodies are typically used in techniques like Western blotting, immunohistochemistry, or ELISA. Despite ongoing studies, the functional significance of PBLD and its antibodies in health and disease warrants further exploration to clarify its potential as a therapeutic or diagnostic target.
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