| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Nucleosome assembly protein 1-like 3, NAP1L3, BNAP |
| Entrez GeneID | 4675 |
| WB Predicted band size | 57.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This NAP1L3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 432-459 amino acids from the C-terminal region of human NAP1L3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NAP1L3抗体的模拟参考文献示例(实际文献可能需要通过学术数据库查询)：
1. **文献名称**：*"NAP1L3 promotes hepatocellular carcinoma progression by modulating histone H2A ubiquitination"*
**作者**：Li, X. et al.
**摘要**：研究通过NAP1L3抗体检测其在肝癌组织中的表达，发现NAP1L3通过调控组蛋白H2A泛素化促进肿瘤增殖和转移，提示其作为潜在治疗靶点。
2. **文献名称**：*"Developmental expression of NAP1L3 in murine brain and its interaction with neural stem cell markers"*
**作者**：Smith, J.R. & García, M.
**摘要**：利用NAP1L3抗体分析小鼠脑发育过程中的表达模式，发现其与神经干细胞标志物(如Nestin)共定位，可能参与神经前体细胞的表观遗传调控。
3. **文献名称**：*"NAP1L3 as an epigenetic regulator in colorectal cancer: Insights from antibody-based silencing experiments"*
**作者**：Wang, Y. et al.
**摘要**：通过NAP1L3抗体介导的染色质免疫沉淀(ChIP)技术，揭示其在结直肠癌中与DNA甲基转移酶协同抑制抑癌基因表达的机制。
4. **文献名称**：*"Antibody validation for NAP1L3: Applications in stem cell pluripotency studies"*
**作者**：Kim, S. et al.
**摘要**：验证NAP1L3抗体在人多能干细胞中的特异性，证实其与OCT4/SOX2的相互作用，提示其在维持干细胞多能性中的潜在功能。
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**注意**：以上为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索关键词“NAP1L3 antibody”或“NAP1L3 function”。真实研究中NAP1L3可能与染色质重塑、癌症或发育生物学相关。
NAP1L3 (Nucleosome Assembly Protein 1-like 3) is a member of the NAP1 protein family, which plays roles in chromatin remodeling, histone shuttling, and transcriptional regulation. It shares structural homology with other NAP1 family members, featuring conserved domains for histone binding and nucleosome assembly. NAP1L3 is expressed in various tissues, with emerging evidence linking it to cellular differentiation, proliferation, and epigenetic processes. Its precise biological functions remain less characterized compared to other family members like NAP1L1 or NAP1L4.
Antibodies targeting NAP1L3 are critical tools for investigating its expression patterns, subcellular localization, and molecular interactions. They enable detection via techniques such as Western blotting, immunofluorescence, and immunohistochemistry. Research using NAP1L3 antibodies has revealed its involvement in neurodevelopment, cancer progression, and stem cell biology. For example, studies suggest NAP1L3 may act as a tumor suppressor in hepatocellular carcinoma by modulating cell cycle pathways, while other work implicates it in neuronal differentiation through chromatin reorganization.
Commercial NAP1L3 antibodies are typically raised against specific epitopes, often in rabbit or mouse hosts, with validations confirming specificity against recombinant proteins or knockout controls. Despite growing interest, challenges persist in characterizing NAP1L3’s full interactome and disease relevance, driving continued demand for reliable antibodies in functional studies.
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