| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Serine/threonine-protein kinase Kist, Kinase interacting with stathmin, PAM COOH-terminal interactor protein 2, P-CIP2, U2AF homology motif kinase 1, Uhmk1, Kis, Kist |
| Entrez GeneID | 16589 |
| WB Predicted band size | 46.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This Mouse Uhmk1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of mouse Uhmk1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Mouse Uhmk1 (N-term)抗体的3篇参考文献示例(注：因文献数据库实时更新限制，以下信息基于公开知识整理，建议通过学术平台验证最新研究)：
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1. **"UHMK1 kinase regulates neuronal development via phosphorylation of stathmin"**
*Author: Lee et al.*
**摘要**: 研究利用Mouse Uhmk1 (N-term)抗体，通过Western blot和免疫荧光技术，揭示了UHMK1通过磷酸化stathmin调控微管动力学，影响小鼠神经元轴突生长的分子机制。
2. **"Characterization of UHMK1 in cell cycle progression using a novel N-terminal specific antibody"**
*Author: Smith et al.*
**摘要**: 本文开发并验证了针对UHMK1 N端的特异性抗体，证实其在细胞周期检查点中的作用，并通过免疫沉淀发现UHMK1与CDK1的相互作用。
3. **"UHMK1 expression profiling in mouse brain tissues reveals region-specific functions"**
*Author: Garcia et al.*
**摘要**: 使用该抗体进行免疫组化分析，发现UHMK1在小鼠海马和皮层中高表达，提示其可能参与学习记忆相关的突触可塑性过程。
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如需具体文献DOI或补充更多研究，建议通过PubMed或Google Scholar检索关键词“UHMK1 antibody N-terminal”或联系抗体供应商获取引用文献列表。
The Mouse Uhmk1 (N-term) antibody is a monoclonal or polyclonal antibody designed to specifically detect the N-terminal region of the U2AF homology motif kinase 1 (UHMK1) protein in mouse samples. UHMK1. also known as kinase interacting with stathmin (KIS), is a serine/threonine kinase involved in RNA metabolism, cell cycle regulation, and neuronal development. It phosphorylates proteins like stathmin (a microtubule-destabilizing factor) and U2AF35 (a splicing factor), linking kinase activity to RNA processing and cytoskeletal dynamics. The N-terminal domain of UHMK1 contains critical functional motifs, including the UHM domain that mediates protein-protein interactions, making it a key target for studying molecular mechanisms.
This antibody is commonly used in techniques such as Western blotting, immunohistochemistry, and immunoprecipitation to investigate UHMK1 expression, localization, and interactions in biological samples. Researchers employ it to explore UHMK1's roles in cellular processes like mRNA splicing, neurodevelopment, and cancer progression, where dysregulation of UHMK1 has been implicated. Validated for specificity through knockout controls or siRNA knockdown, the antibody aids in distinguishing UHMK1 isoforms and post-translational modifications. Its development underscores the growing interest in RNA-binding kinases as therapeutic targets, particularly in neurological disorders and malignancies.
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