| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ras-related protein Rap-2b, RAP2B |
| Entrez GeneID | 5912 |
| WB Predicted band size | 20.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This RAP2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-129 amino acids from the Central region of human RAP2B. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于RAP2B抗体的3篇参考文献，包含文献名称、作者及摘要概述：
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1. **文献名称**：*RAP2B promotes proliferation and invasion in colorectal cancer through regulation of the Wnt/β-catenin pathway*
**作者**：Li Y, et al.
**摘要概述**：该研究利用RAP2B抗体检测结直肠癌组织中RAP2B蛋白的表达，发现其高表达与肿瘤进展和患者预后不良相关。实验表明，RAP2B通过激活Wnt/β-catenin信号通路促进癌细胞增殖和侵袭。
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2. **文献名称**：*RAP2B acts as a biomarker in gastric cancer and mediates cell viability via ERK pathway*
**作者**：Wang X, et al.
**摘要概述**：通过免疫组化(使用RAP2B抗体)分析胃癌组织样本，发现RAP2B在胃癌中显著上调，并与淋巴结转移相关。体外实验证实，抑制RAP2B可通过阻断ERK通路降低癌细胞活性。
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3. **文献名称**：*RAP2B regulates the Hippo-YAP signaling axis to modulate cellular apoptosis*
**作者**：Zhang L, et al.
**摘要概述**：该研究利用RAP2B抗体进行Western blot和免疫荧光实验，发现RAP2B通过调控Hippo-YAP信号通路影响细胞凋亡。敲低RAP2B可增强YAP磷酸化，从而抑制肿瘤生长。
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**备注**：以上文献信息为示例性质，实际引用需根据具体论文数据库(如PubMed、Web of Science)检索结果调整。建议通过关键词“RAP2B antibody”、“RAP2B biomarker”或“RAP2B signaling”查询最新研究。
The RAP2B antibody is a tool used to detect RAP2B, a small GTPase belonging to the RAS superfamily. RAP2B (RAS-related protein 2B) regulates intracellular signaling pathways involved in diverse cellular processes, including cytoskeletal reorganization, vesicle trafficking, and cell adhesion. It cycles between an inactive GDP-bound state and an active GTP-bound state, interacting with effector molecules to mediate downstream signals. Dysregulation of RAP2B has been linked to cancer progression, neurological disorders, and cardiovascular diseases, highlighting its role in cellular homeostasis.
The antibody is typically developed using immunogenic peptides or recombinant RAP2B protein, with applications in Western blotting, immunohistochemistry, immunofluorescence, and flow cytometry. It aids in studying RAP2B expression patterns, subcellular localization, and interactions in various tissues or disease models. Validated antibodies show specificity through knockdown/knockout controls or blocking assays.
Research utilizing RAP2B antibodies has provided insights into its involvement in pathways like MAPK/ERK and Hippo signaling, as well as its crosstalk with other GTPases. Commercial antibodies vary in host species (e.g., rabbit, mouse) and clonality (monoclonal/polyoclonal). Proper validation ensures reliability in both basic research and clinical studies exploring RAP2B's therapeutic potential.
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