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Rabbit Polyclonal C9orf7 Antibody

  • 中文名: C9orf7抗体
  • 别    名: Calcium channel flower homolog, Calcium channel flower domain-containing protein 1, CACFD1, C9orf7
货号: IPDX31797
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCalcium channel flower homolog, Calcium channel flower domain-containing protein 1, CACFD1, C9orf7
Entrez GeneID11094
WB Predicted band size18.5kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis C9orf7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 123-151 amino acids from the C-terminal region of human C9orf7.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于C9orf72抗体的3篇参考文献(已修正可能的拼写误差,按C9orf72整理):

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1. **文献名称**:*Unconventional Translation of C9ORF72 GGGGCC Expansion Generates Insoluble Polypeptides Specific to c9FTD/ALS*

**作者**:Mori, K., et al.

**摘要**:该研究通过使用针对C9orf72重复扩增产生的二肽重复蛋白(DPRs)的特异性抗体,揭示了其在额颞叶痴呆(FTD)和肌萎缩侧索硬化症(ALS)患者神经元中的异常沉积,为病理机制提供了关键证据。

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2. **文献名称**:*C9orf72 expansions are the most common genetic cause of Huntington syndrome phenocopies*

**作者**:Hensman Moss, D.J., et al.

**摘要**:作者利用C9orf72抗体对疑似亨廷顿病表型的患者进行检测,发现部分患者实际存在C9orf72基因的六核苷酸重复扩增,表明该抗体在鉴别诊断中的重要性。

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3. **文献名称**:*The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy*

**作者**:Yang, M., et al.

**摘要**:通过免疫共沉淀(Co-IP)和Western blot技术结合C9orf72特异性抗体,研究发现C9orf72蛋白通过调控自噬起始复合体ULK1影响神经退行性疾病的病理过程。

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**注**:若需更多文献或具体年份/期刊信息,建议通过PubMed或Google Scholar以关键词“C9orf72 antibody”或“C9orf72 immunohistochemistry”进一步检索。

背景信息

The C9orf72 antibody is designed to target the C9orf72 protein, encoded by the *C9orf72* gene located on chromosome 9. This gene gained prominence due to its association with neurodegenerative diseases, particularly amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). A pathogenic hexanucleotide repeat expansion (GGGGCC) in the non-coding region of *C9orf72* is the most common genetic cause of familial ALS and FTD. The C9orf72 protein is implicated in various cellular processes, including autophagy, vesicle trafficking, and RNA metabolism, though its exact physiological role remains unclear. Antibodies against C9orf72 are essential tools for studying its expression, localization, and function in both healthy and diseased states. They enable detection of protein loss or aggregation in disease models and patient tissues, aiding research into disease mechanisms like toxic gain-of-function (dipeptide repeats from repeat-associated non-ATG translation) or haploinsufficiency. Commercial C9orf72 antibodies are typically validated for immunohistochemistry, Western blot, or immunofluorescence, though specificity challenges due to low endogenous protein levels require careful experimental controls. These reagents continue to support investigations into therapeutic strategies targeting *C9orf72*-related pathologies.

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