| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Fasciculation and elongation protein zeta-2, Zygin II, Zygin-2, FEZ2 |
| Entrez GeneID | 9637 |
| WB Predicted band size | 39.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | This FEZ2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human FEZ2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于FEZ2(N-terminal)抗体的参考文献示例(内容为模拟，建议通过学术数据库核实具体文献)：
1. **文献名称**：*FEZ2 regulates axonal outgrowth through interactions with microtubule-associated proteins*
**作者**：Smith A, et al.
**摘要**：本研究利用FEZ2(N-term)特异性抗体，揭示了FEZ2蛋白通过结合微管相关蛋白MAP1B调控轴突生长的机制，为神经发育障碍研究提供了新方向。
2. **文献名称**：*Characterization of FEZ2 isoforms and their roles in neuronal differentiation*
**作者**：Chen L, et al.
**摘要**：通过FEZ2 N端抗体识别不同异构体，发现FEZ2-L在神经元分化中显著上调，并通过激活Wnt信号通路促进突触形成。
3. **文献名称**：*A novel monoclonal antibody against FEZ2 N-terminus for detecting protein expression in Alzheimer's disease models*
**作者**：Yamamoto K, et al.
**摘要**：开发了一种高特异性FEZ2(N-term)单克隆抗体，应用于阿尔茨海默病小鼠模型，发现FEZ2表达水平与tau蛋白异常磷酸化呈负相关。
4. **文献名称**：*Proteomic analysis of FEZ2-interacting proteins using N-terminal epitope tagging*
**作者**：Gomez-Ramos P, et al.
**摘要**：通过N端标记的FEZ2抗体进行免疫共沉淀，鉴定出14-3-3ε和DISC1等新型相互作用蛋白，提示FEZ2在精神疾病中的潜在作用。
建议通过PubMed或Google Scholar以“FEZ2 antibody N-terminal”为关键词检索最新文献以获取具体信息。
The FEZ2 (N-term) antibody is designed to target the N-terminal region of the Fasciculation and Elongation Protein Zeta-2 (FEZ2), a member of the FEZ protein family implicated in neuronal development and intracellular transport. FEZ2. also known as UNC-76 in *C. elegans*, shares homology with its paralog FEZ1 and plays roles in axonal outgrowth, synaptic vesicle trafficking, and neuronal polarity. It interacts with kinesin motors and adaptor proteins to regulate cargo transport along microtubules. The N-terminal domain of FEZ2 is critical for its oligomerization and binding to partner proteins, influencing its functional specificity.
This antibody is commonly used in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to study FEZ2 expression, localization, and interactions in neural tissues or cultured cells. Its specificity for the N-terminal region allows differentiation from FEZ1 and detection of full-length FEZ2 isoforms. Research involving FEZ2 (N-term) antibodies has contributed to understanding neurodevelopmental disorders, neurodegenerative diseases (e.g., Alzheimer's), and cancer, where FEZ2 dysregulation is observed. Validation often includes knockout controls or peptide-blocking assays to confirm target recognition.
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