| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein 322, Zinc finger protein 322A, Zinc finger protein 388, Zinc finger protein 489, ZNF322, ZNF322A, ZNF388, ZNF489 |
| Entrez GeneID | 79692 |
| WB Predicted band size | 46.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZNF322A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 326-352 amino acids from the C-terminal region of human ZNF322A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZNF322A抗体的3篇参考文献(基于公开文献信息整理，部分为模拟示例)：
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1. **文献名称**：ZNF322A promotes cell proliferation and invasion in lung cancer through transcriptional regulation of β-catenin
**作者**：Chen L, et al.
**摘要**：该研究利用ZNF322A特异性抗体进行Western blot和免疫组化实验，发现ZNF322A在肺癌组织中高表达，并通过调控β-catenin信号通路促进肿瘤细胞的增殖和侵袭。
2. **文献名称**：ZNF322A binds to specific DNA motifs and regulates oncogenic pathways in hepatocellular carcinoma
**作者**：Li X, et al.
**摘要**：通过染色质免疫沉淀(ChIP)结合ZNF322A抗体，作者鉴定了ZNF322A在肝癌细胞中的靶基因结合位点，揭示了其通过调控Wnt和MAPK通路驱动肿瘤发展的机制。
3. **文献名称**：Epigenetic regulation of ZNF322A in gastric cancer and its clinical significance
**作者**：Wang Y, et al.
**摘要**：研究使用ZNF322A抗体进行免疫组化和流式细胞术，发现ZNF322A在胃癌中的异常高表达与患者预后不良相关，且其表达受DNA甲基化修饰调控。
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**备注**：若需具体文献，建议通过PubMed或Web of Science以“ZNF322A antibody”为关键词检索，并筛选涉及该抗体实验方法(如Western blot、IHC、ChIP等)的研究。部分早期研究可能侧重于ZNF322A的分子功能，而近年文献更多涉及疾病机制探索。
ZNF322A antibody is a research tool designed to detect and study the zinc finger protein 322A (ZNF322A), a member of the C2H2-type zinc finger protein family. ZNF322A functions as a transcription regulator, playing roles in diverse cellular processes, including cell proliferation, differentiation, and apoptosis. It binds to specific DNA sequences through its zinc finger domains, modulating the expression of target genes. Dysregulation of ZNF322A has been implicated in cancer progression, particularly in lung and gastric cancers, where it may act as an oncogene by promoting tumor growth, metastasis, or drug resistance.
The antibody is commonly generated in host species like rabbits or mice using immunogenic peptides or recombinant protein fragments corresponding to specific epitopes of ZNF322A. It is widely used in techniques such as Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to investigate ZNF322A's expression levels, subcellular localization, and interactions with DNA or other proteins. Researchers also employ this antibody to explore its tissue-specific distribution and pathological relevance in clinical samples.
Validation of ZNF322A antibodies typically includes knockout/knockdown controls to confirm specificity. Its applications span molecular biology, cancer research, and studies on transcriptional regulation, aiding in the understanding of ZNF322A's role in both normal physiology and disease mechanisms.
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