| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Immediate early response gene 5 protein, IER5 |
| Entrez GeneID | 51278 |
| WB Predicted band size | 33.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This IER5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-149 amino acids from the Central region of human IER5. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于IER5抗体的3篇参考文献示例(注：以下内容为模拟生成，实际文献需通过学术数据库检索确认)：
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1. **文献名称**: *IER5 as a Novel Biomarker in Colorectal Cancer: Expression Analysis Using a Specific Polyclonal Antibody*
**作者**: Takahashi, Y., et al.
**摘要**: 本研究开发了一种针对IER5蛋白的多克隆抗体，并验证其在结直肠癌组织中的特异性表达。免疫组化分析显示IER5高表达与患者不良预后相关，提示其作为潜在生物标志物的价值。
2. **文献名称**: *The Role of IER5 in DNA Damage Response: Insights from Antibody-mediated Knockdown Studies*
**作者**: Chen, L., & Wang, H.
**摘要**: 通过使用特异性IER5抗体进行蛋白敲低实验，研究发现IER5通过调控ATM/ATR信号通路参与DNA损伤修复。抗体在Western blot和免疫荧光中的高效性为机制研究提供了工具支持。
3. **文献名称**: *Development of a Monoclonal Antibody for IER5 and Its Application in Heat Shock Response Research*
**作者**: Müller, S., et al.
**摘要**: 本文报道了一种高亲和力IER5单克隆抗体的开发，并应用于热休克条件下细胞模型的蛋白定位分析。结果显示IER5与HSP70存在共定位，提示其在应激反应中的协同作用。
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如需获取真实文献，建议通过PubMed或Web of Science检索关键词"IER5 antibody"或"IER5 immunohistochemistry"，并筛选近5年内的实验研究类论文。
The IER5 (Immediate Early Response 5) antibody is a tool used to detect the IER5 protein, a member of the immediate early response gene family. These genes are rapidly activated in response to extracellular stimuli, such as stress, growth factors, or cell cycle changes. IER5. also known as IER5L or PP3117. encodes a nuclear protein implicated in transcriptional regulation, cell cycle control, and DNA damage response. Studies suggest its involvement in modulating the heat shock response by interacting with HSF1 (Heat Shock Factor 1) and influencing phosphorylation states of stress-related signaling pathways.
IER5 expression is linked to cancer biology, showing differential expression in malignancies like colorectal and liver cancers. It may act as a tumor suppressor or oncogene depending on context, with roles in apoptosis, chemotherapy sensitivity, and radiation response. The IER5 antibody is widely used in research applications (e.g., Western blotting, immunohistochemistry) to study its expression patterns, subcellular localization, and interactions in cellular stress models or cancer progression. Commercially available antibodies are typically raised against specific epitopes, with validation in human, mouse, or rat samples. Understanding IER5's regulatory mechanisms remains critical for exploring its potential as a therapeutic target or biomarker in stress-related diseases and oncology.
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