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Rabbit Polyclonal ANP32C Antibody

  • 中文名: ANP32C抗体
  • 别    名: Acidic leucine-rich nuclear phosphoprotein 32 family member C, Phosphoprotein 32-related protein 1, Tumorigenic protein pp32r1, ANP32C, PP32R1
货号: IPDX31783
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesAcidic leucine-rich nuclear phosphoprotein 32 family member C, Phosphoprotein 32-related protein 1, Tumorigenic protein pp32r1, ANP32C, PP32R1
Entrez GeneID23520
WB Predicted band size26.8kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis ANP32C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 130-158 amino acids from the Central region of human ANP32C.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于ANP32C抗体的3篇模拟文献参考(内容为虚构示例,仅供格式参考):

1. **文献名称**: *ANP32C modulates chromatin remodeling in lung cancer via histone acetylation*

**作者**: Li, X.; Chen, Y.; Wang, T.

**摘要**: 本研究利用ANP32C特异性抗体进行免疫沉淀及Western blot分析,揭示了ANP32C通过与组蛋白去乙酰化酶(HDACs)相互作用调控染色质结构,促进肺癌细胞增殖的分子机制。

2. **文献名称**: *Development of a monoclonal antibody against ANP32C for viral replication studies*

**作者**: Smith, J.; Patel, R.; García-Sastre, A.

**摘要**: 文章报道了一种高特异性ANP32C单克隆抗体的开发,并验证其在流感病毒复制中的作用。通过抗体介导的蛋白敲低实验,证实ANP32C对病毒RNA聚合酶活性具有辅助功能。

3. **文献名称**: *ANP32C as a potential biomarker in colorectal cancer: Insights from immunohistochemical analysis*

**作者**: Kim, S.; Tanaka, H.; Zhang, L.

**摘要**: 使用ANP32C抗体对结直肠癌组织进行免疫组化分析,发现其表达水平与肿瘤分期和患者预后显著相关,提示其作为临床诊断标志物的潜力。

(注:以上文献为示例性虚构内容,实际研究需通过学术数据库检索确认。)

背景信息

ANP32C (Acidic Nuclear Phosphoprotein 32 Family Member C) is a member of the ANP32 protein family, which is characterized by conserved N-terminal leucine-rich repeats and a C-terminal acidic tail. These proteins are involved in diverse cellular processes, including chromatin remodeling, RNA transport, and regulation of apoptosis. ANP32C, specifically, has been implicated in modulating protein phosphatase 2A (PP2A) activity, a key regulator of cell signaling pathways. It also interacts with influenza A virus polymerase, facilitating viral replication by stabilizing viral RNA synthesis machinery in host cells.

Antibodies targeting ANP32C are critical tools for studying its biological functions and disease associations. They enable the detection and localization of ANP32C in tissues and cultured cells through techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research using these antibodies has revealed ANP32C's role in cancer progression, neurodevelopment, and viral pathogenesis. For example, elevated ANP32C expression correlates with poor prognosis in certain cancers, possibly due to its influence on oncogenic signaling pathways. Additionally, studies in knockout models highlight its importance in neural development and synaptic plasticity.

The development of ANP32C-specific antibodies faces challenges due to high sequence homology within the ANP32 family. Validation strategies, such as siRNA knockdown and cross-reactivity testing, are essential to ensure specificity. These antibodies not only advance basic research but also hold potential for therapeutic applications, particularly in targeting virus-host interactions or dysregulated pathways in diseases like cancer.

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