| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Potassium voltage-gated channel subfamily S member 3, Delayed-rectifier K(+) channel alpha subunit 3, Voltage-gated potassium channel subunit Kv93, KCNS3 |
| Entrez GeneID | 3790 |
| WB Predicted band size | 56.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This KCNS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human KCNS3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于KCNS3(N-term)抗体的参考文献示例(注：以下内容为虚构示例，实际文献需通过学术数据库检索确认)：
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1. **文献名称**：**"Development and Validation of a KCNS3 N-Terminal Antibody for Neurodegenerative Disease Research"**
**作者**：Thompson R, et al.
**摘要**：本研究开发了一种特异性靶向KCNS3蛋白N端结构域的多克隆抗体，并通过Western blot和免疫荧光验证了其在人脑组织中的结合特异性。研究发现KCNS3在阿尔茨海默病模型中表达异常，提示其可能参与神经元兴奋性调控。
2. **文献名称**：**"KCNS3 Channel Expression in Glioblastoma: Role of a Novel N-Terminal Antibody in Tumor Profiling"**
**作者**：Zhang L, et al.
**摘要**：利用KCNS3(N-term)抗体分析胶质母细胞瘤样本，发现KCNS3在肿瘤边缘高表达，并与患者生存率相关。抗体通过免疫组化验证，证实其适用于临床组织标本的检测。
3. **文献名称**：**"Electrophysiological and Immunochemical Analysis of KCNS3 in Dorsal Root Ganglia Neurons"**
**作者**：Müller S, et al.
**摘要**：结合膜片钳技术和KCNS3 N端抗体标记，研究证实KCNS3在背根神经节神经元中的分布与慢性疼痛模型的钾电流减弱相关，抗体特异性通过基因敲除小鼠验证。
4. **文献名称**：**"Commercial Antibody Validation for KCNS3: Challenges and Solutions in Epitope-Specific Binding"**
**作者**：BioTech Antibody Solutions Team
**摘要**：评估了市售KCNS3(N-term)抗体的可靠性，通过肽竞争实验和siRNA敲低证明其特异性，并提供了优化实验条件(如抗原修复方法)以提高检测准确性。
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**备注**：以上文献为示例性质，实际引用需以具体检索结果为准。建议通过PubMed、Web of Science等平台搜索关键词“KCNS3 antibody N-terminal”或联系抗体供应商获取技术文献。
The KCNS3 (N-term) antibody is a research tool designed to detect the KCNS3 protein, specifically targeting its N-terminal region. KCNS3. also known as Kv9.3. is a member of the voltage-gated potassium (Kv) channel family, which regulates neuronal excitability by modulating action potential repolarization and firing frequency. It belongs to the "silent" Kv subunit subfamily (Kv5. Kv6. Kv8. Kv9), as it does not form functional homomeric channels but modulates the activity of pore-forming Kv2 subunits by altering their gating properties, expression levels, or subcellular localization.
This antibody is commonly used in Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study KCNS3 expression patterns in various tissues, particularly in the nervous system. Its specificity for the N-terminal domain allows researchers to distinguish KCNS3 from other Kv subunits with conserved transmembrane regions. KCNS3 has been implicated in neurological disorders, including epilepsy, neuropathic pain, and schizophrenia, making this antibody valuable for exploring disease mechanisms. Validation typically includes testing on recombinant KCNS3 or cell lines overexpressing the protein, with observed molecular weights around 50-55 kDa. Researchers frequently employ it to investigate KCNS3's role in neuronal signaling plasticity and its interaction partners under physiological or pathological conditions.
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