| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Serine/threonine-protein kinase SBK2, SH3-binding domain kinase family member 2, Sugen kinase 69, SgK069, Sbk2, Sgk069 |
| Entrez GeneID | 381836 |
| WB Predicted band size | 39.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This Mouse Sbk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 293-320 amino acids from the C-terminal region of mouse Sbk2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Mouse Sbk2抗体的假设性参考文献(注：SBK2相关研究较少，以下内容为模拟示例，实际文献可能需要进一步检索验证)：
1. **文献名称**: "Characterization of SBK2 in cerebellar development using a novel monoclonal antibody"
**作者**: Smith A, et al.
**摘要**: 本研究开发了一种特异性识别小鼠SBK2蛋白的单克隆抗体，通过免疫印迹和免疫组化验证其有效性，并发现SBK2在小脑颗粒神经元分化中调控细胞周期进程。
2. **文献名称**: "SBK2 modulates neuronal migration via cytoskeletal dynamics in mice"
**作者**: Chen L, et al.
**摘要**: 利用SBK2多克隆抗体进行免疫荧光定位，揭示了SBK2与动力蛋白复合体相互作用，影响皮层神经元迁移过程中的微管重组。
3. **文献名称**: "Generation and application of polyclonal antibodies against mouse SBK2 kinase"
**作者**: Johnson R, et al.
**摘要**: 首次报道了小鼠SBK2多克隆抗体的制备，通过抗原表位肽免疫兔获得抗体，证实其在Western blot及免疫沉淀中的特异性，并用于检测SBK2在胚胎组织中的表达谱。
4. **文献名称**: "SBK2 regulates G1/S transition in stem cells: Evidence from antibody-mediated knockdown"
**作者**: Yamamoto K, et al.
**摘要**: 采用SBK2抗体进行功能阻断实验，证明SBK2通过磷酸化CDK抑制剂p27.促进胚胎干细胞的G1/S期转换，抗体特异性经敲除细胞系验证。
**提示**：实际研究中，SBK2可能涉及不同功能领域(如神经发育、癌症)，建议结合具体研究目标筛选文献。若检索困难，可尝试扩大关键词(如“SBK2 kinase antibody”)或联系抗体生产商获取引用文献。
The Mouse Sbk2 (SH3-Binding Kinase 2) antibody is a tool used to study the SBK2 protein, a serine/threonine kinase encoded by the *Sbk2* gene in mice. SBK2 belongs to the SBK/SPAK kinase family and is implicated in regulating cellular processes such as signal transduction, cytoskeletal organization, and neuronal development. Its expression is particularly notable in the brain, where it may influence synaptic plasticity and neural circuit formation. The exact biological functions of SBK2 remain under investigation, but its interaction with SH3 domain-containing proteins suggests roles in protein-protein signaling networks.
The antibody, typically generated in rabbits or mice using immunogenic peptides derived from the mouse SBK2 protein, enables the detection and localization of SBK2 in various experimental applications, including Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). It is validated for specificity to ensure minimal cross-reactivity with related kinases like SBK1 or other family members. Researchers utilize this antibody to explore SBK2's expression patterns, post-translational modifications, and involvement in disease models, such as neurological disorders or cancer. Its development supports advancing studies on kinase-mediated signaling pathways and their physiological or pathological impacts in murine systems.
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